Stress and nerve growth factor - Findings in animal models and humans

被引：111

作者：

Aloe, L

Alleva, E

Fiore, M

机构：

[1] CNR, Ist Neurobiol & Med Mol, I-00137 Rome, Italy

[2] Ist Super Sanita, Lab Fisiopatol Organo & Sistema, I-00161 Rome, Italy

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 2002年 / 73卷 / 01期

关键词：

NGF; stress; schizophrenia; electroconvulsive treatment; environmental changes; neurotrophin; behavior;

D O I：

10.1016/S0091-3057(02)00757-8

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Stress is elicited by environmental, social or pathological conditions occurring during the life of animals and humans that determine changes in the nervous, endocrine and immune systems. In the present review, we present data supporting the hypothesis that stress-related events both in animal models and humans are characterized by modifications of endogenous nerve growth factor (NGF) synthesis and/or utilization. Stress inducing alteration in NGF synthesis and/or utilization appears to be more severe during neurogenesis and in early postnatal life. However, NGF endogenously released during stress may promote remodeling of damaged tissues following acute and/or chronic stressful events. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：159 / 166

页数：8

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