Putative inflammatory and immunological mechanisms in functional bowel disorders

被引：42

作者：

Collins, SM

Vallance, B

Barbara, G

Borgaonkar, M

机构：

[1] McMaster Univ, Med Ctr, Div Gastroenterol, Intestinal Dis Res Unit, Hamilton, ON L8N 3Z5, Canada

[2] Univ Bologna, Dept Med, Div Gastroenterol, Bologna, Italy

来源：

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY | 1999年 / 13卷 / 03期

关键词：

inflammation; infection; gastroenteritis; immune system; lymphocytes; mast cells; cytokines; colitis; inflammatory bower disease; smooth muscle; enteric nerves; sensory nerves; asthma;

D O I：

10.1053/bega.1999.0037

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The observations that irritable bowel syndrome (IBS) may be precipitated by an acute enteric infection, or occurs commonly in patients in remission from inflammatory bowel disease (IBD) has prompted consideration of inflammation as a putative basis for symptom generation in IBS. In this regard, IBS may follow a pattern of pathogenesis that is similar to asthma-which was once considered a psychosomatic disease. This review examines the basic scientific evidence of a functional interface between the immune and sensory-motor systems of the gut and discusses how this may be relevant to a subgroup of IBS patients. In addition, review will examine the implications of this for the diagnosis and treatment of IBS.

引用

页码：429 / 436

页数：8

共 39 条

[1]

ABRAMS GD, 1967, P SOC EXP BIOL MED, V126, P301

[2] On the mechanism underlying post-infective intestinal dysfunction. [J].