A protective role for innate immunity in systemic lupus erythematosus

被引：121

作者：

Carroll, MC ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, CBR Inst Biomed Res Inc, Boston, MA 02115 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2004年 / 4卷 / 10期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nri1456

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Clinical and genetic studies in humans and animal models indicate a crucial protective role for the complement system in systemic lupus erythematosus (SLE). This presents a paradox because the complement system is considered to be an important mediator of the inflammation that is observed in patients with SLE. One current view is that complement provides protection by facilitating the rapid removal of apoptotic debris to circumvent an autoimmune response. In this Opinion article, I discuss an alternative model in which complement - together with other components of the innate immune system - participates in the 'presentation' of SLE-inducing self-antigens to developing B cells. In this way, the complement system and innate immunity protect against responses to SLE ( self) antigens by enhancing the elimination of self-reactive lymphocytes.

引用

页码：825 / 831

页数：7

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