Somatic cell nuclear transfer

被引：366

作者：

Wilmut, I ^{[1
]}

Beaujean, N

de Sousa, PA

Dinnyes, A

King, TJ

Paterson, LA

Wells, DN

Young, LE

机构：

[1] Roslin Inst, Roslin EH25 9PS, Midlothian, Scotland

[2] AgResearch, Hamilton, New Zealand

来源：

NATURE | 2002年 / 419卷 / 6907期

关键词：

D O I：

10.1038/nature01079

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cloning by nuclear transfer from adult somatic cells is a remarkable demonstration of developmental plasticity. When a nucleus is placed in oocyte cytoplasm, the changes in chromatin structure that govern differentiation can be reversed, and the nucleus can be made to control development to term.

引用

页码：583 / 586

页数：4

共 43 条

[1] Factors controlling the loss of immunoreactive somatic histone H1 from blastomere nuclei in oocyte cytoplasm: A potential marker of nuclear reprogramming [J].