Necrosis, a well-orchestrated form of cell demise: Signalling cascades, important mediators and concomitant immune response

被引:524
作者
Festjens, Nele [1 ]
Vanden Berghe, Tom [1 ]
Vandenabeele, Peter [1 ]
机构
[1] Univ Ghent VIB, Dept Mol Biomed Res, Mol Signalling & Cell Death Unit, B-9052 Ghent, Belgium
来源
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | 2006年 / 1757卷 / 9-10期
关键词
calcium; inflammation; mitochondria; phospholipases; proteases; ROS;
D O I
10.1016/j.bbabio.2006.06.014
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Necrosis has long been described as a consequence of physico-chemical stress and thus accidental and uncontrolled. Recently, it is becoming clear that necrotic cell death is as well controlled and programmed as caspase-dependent apoptosis, and that it may be an important cell death mode that is both pathologically and physiologically relevant. Necrotic cell death is not the result of one well-described signalling cascade but is the consequence of extensive crosstalk between several biochemical and molecular events at different cellular levels. Recent data indicate that serine/threonine kinase RIP1, which contains a death domain, may act as a central initiator. Calcium and reactive oxygen species (ROS) are main players during the propagation and execution phases of necrotic cell death, directly or indirectly provoking damage to proteins, lipids and DNA, which culminates in disruption of organelle and cell integrity. Necrotically dying cells initiate pro-inflammatory signalling cascades by actively releasing inflammatory cytokines and by spilling their contents when they lyse. Unravelling the signalling cascades contributing to necrotic cell death will permit us to develop tools to specifically interfere with necrosis at certain levels of signalling. Necrosis occurs in both physiological and pathophysiological processes, and is capable of killing tumour cells that have developed strategies to evade apoptosis. Thus detailed knowledge of necrosis may be exploited in therapeutic strategies. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码:1371 / 1387
页数:17
相关论文
共 240 条
[1]   Regulatory pathways in photodynamic therapy induced apoptosis [J].
Agostinis, P ;
Buytaert, E ;
Breyssens, H ;
Hendrickx, N .
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, 2004, 3 (08) :721-729
[2]   Inflammation and Alzheimer's disease [J].
Akiyama, H ;
Barger, S ;
Barnum, S ;
Bradt, B ;
Bauer, J ;
Cole, GM ;
Cooper, NR ;
Eikelenboom, P ;
Emmerling, M ;
Fiebich, BL ;
Finch, CE ;
Frautschy, S ;
Griffin, WST ;
Hampel, H ;
Hull, M ;
Landreth, G ;
Lue, LF ;
Mrak, R ;
Mackenzie, IR ;
McGeer, PL ;
O'Banion, MK ;
Pachter, J ;
Pasinetti, G ;
Plata-Salaman, C ;
Rogers, J ;
Rydel, R ;
Shen, Y ;
Streit, W ;
Strohmeyer, R ;
Tooyoma, I ;
Van Muiswinkel, FL ;
Veerhuis, R ;
Walker, D ;
Webster, S ;
Wegrzyniak, B ;
Wenk, G ;
Wyss-Coray, T .
NEUROBIOLOGY OF AGING, 2000, 21 (03) :383-421
[3]   Poly(ADP-ribose) polymerase-1-mediated cell death in astrocytes requires NAD+ depletion and mitochondrial permeability transition [J].
Alano, CC ;
Ying, WH ;
Swanson, RA .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (18) :18895-18902
[4]   Nitric oxide synthases: structure, function and inhibition [J].
Alderton, WK ;
Cooper, CE ;
Knowles, RG .
BIOCHEMICAL JOURNAL, 2001, 357 (03) :593-615
[5]   Intracellular signaling mechanisms in photodynamic therapy [J].
Almeida, RD ;
Manadas, BJ ;
Carvalho, AP ;
Duarte, CB .
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2004, 1704 (02) :59-86
[6]   Mitochondrial metabolism of reactive oxygen species [J].
Andreyev, AI ;
Kushnareva, YE ;
Starkov, AA .
BIOCHEMISTRY-MOSCOW, 2005, 70 (02) :200-214
[7]   Annexin I is an endogenous ligand that mediates apoptotic cell engulfment [J].
Arur, S ;
Uche, UE ;
Rezaul, K ;
Fong, M ;
Scranton, V ;
Cowan, AE ;
Mohler, W ;
Han, DK .
DEVELOPMENTAL CELL, 2003, 4 (04) :587-598
[8]   Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death [J].
Baines, CP ;
Kaiser, RA ;
Purcell, NH ;
Blair, NS ;
Osinska, H ;
Hambleton, MA ;
Brunskill, EW ;
Sayen, MR ;
Gottlieb, RA ;
Dorn, GW ;
Robbins, J ;
Molkentin, JD .
NATURE, 2005, 434 (7033) :658-662
[9]   Cardiac energy metabolism homeostasis: Role of cytosolic calcium [J].
Balaban, RS .
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2002, 34 (10) :1259-1271
[10]   Alpha/beta interferons potentiate virus-induced apoptosis through activation of the FADD/caspase-8 death signaling pathway [J].
Balachandran, S ;
Roberts, PC ;
Kipperman, T ;
Bhalla, KN ;
Compans, RW ;
Archer, DR ;
Barber, GN .
JOURNAL OF VIROLOGY, 2000, 74 (03) :1513-1523