Transforming growth factor-beta 1 promotes re-elongation of injured axons of cultured rat hippocampal neurons

被引：46

作者：

Abe, K

Chu, PJ

Ishihara, A

Saito, H

机构：

[1] Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo

来源：

BRAIN RESEARCH | 1996年 / 723卷 / 1-2期

关键词：

transforming growth factor-beta 1; neurite regeneration; cultured hippocampal neuron;

D O I：

10.1016/0006-8993(96)00253-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Transforming growth factor-beta 1 (TGF-beta 1) is highly expressed in neural tissues following brain injuries. To determine a role of TGF-beta 1 in neural pathologies, axons of cultured rat hippocampal neurons were cut by local irradiation of laser beam, and the effect of TGF-beta 1 on neurite regeneration following axotomy was investigated. The axonal growth was stopped by laser irradiation, but addition of TGE-beta 1 remarkably promoted the axonal re-elongation from the injured site. The effect of TGF-beta 1 was concentration dependent and seen maximally at a concentration of 1 ng/ml. These results suggest that TGF-beta 1 has a capability of promoting axonal regeneration of brain neurons after lesioning.

引用

页码：206 / 209

页数：4

共 25 条

[1] EFFECTS OF RECOMBINANT HUMAN BASIC FIBROBLAST GROWTH-FACTOR AND ITS MODIFIED PROTEIN CS23 ON SURVIVAL OF PRIMARY CULTURED NEURONS FROM VARIOUS REGIONS OF FETAL-RAT BRAIN [J].