Inhibition of nitric oxide synthase prevents magnesium-free-induced epileptiform activity in guinea-pig piriform cortex neurones in vitro

被引:12
作者
Libri, V
Santarelli, R
Nistico, S
Azzena, GB
机构
[1] UNIV ROMA TOR VERGATA, DEPT BIOL, I-00173 ROME, ITALY
[2] UNIV CATTOLICA SACRO CUORE, FAC MED, INST HUMAN PHYSIOL, I-00168 ROME, ITALY
关键词
magnesium-free-induced epileptiform activity; NMDA receptor; nitric oxide synthase inhibitors; synaptic transmission; piriform cortex; intracellular recording;
D O I
10.1007/PL00004968
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The effects of N-nitro-L-arginine methyl ester (L-NAME), a nitric oxide (NO) synthase inhibitor, were examined on Mg2+-free-induced epileptiform activity, in guinea-pig piriform cortex slices in vitro. L-NAME (0.1-1 mM) had no effect on neuronal membrane properties or electrically-evoked postsynaptic potentials (PSPs). In contrast, during superfusion of the slices with Mg2+-free solution neurones exhibited spontaneous and stimulus-evoked epileptiform potentials that were suppressed in the presence of L-NAME (100 mu M) or the selective NMDA receptor antagonist DL-APV (100 mu M). The inhibitory effects induced by L-NAME were reversibly reduced by L-arginine (1 mM), but not D-arginine (1 mM), the latter drug not being a substrate for NO formation. It was concluded that L-NAME can suppress epileptiform activity induced by Mg2+-free exposure primarily through a decrease in presynaptic transmitter release, although additional actions on the NMDA-receptor complex were also considered.
引用
收藏
页码:452 / 456
页数:5
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