Genetic, antigenic and serologic characterization of human immunodeficiency virus type 1 from Indonesia

被引：31

作者：

Porter, KR

Mascola, JR

Hupudio, H

Ewing, D

VanCott, TC

Anthony, RL

Corwin, AL

Widodo, S

Ertono, S

McCutchan, FE

Burke, DS

Hayes, CG

Wignall, FS

Graham, RR

机构：

[1] NATL NAVAL MED CTR, VIRAL & RICKETTSIAL DIS PROGRAM, DEPT INFECT DIS, BETHESDA, MD 20814 USA

[2] NAVAL MED RES UNIT 2, DEPT VIROL, JAKARTA, INDONESIA

[3] CTR DIS CONTROL, P2LP, JAKARTA, INDONESIA

[4] WALTER REED ARMY INST RES, DIV RETROVIROL, ROCKVILLE, MD USA

[5] HENRY M JACKSON FDN, ROCKVILLE, MD USA

[6] GATOT SUBROTO ARMY HOSP, JAKARTA, INDONESIA

[7] DIRECTORATE HLTH, ARMY HEADQUARTERS, JAKARTA, INDONESIA

来源：

JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY | 1997年 / 14卷 / 01期

关键词：

HIV-1; genotype; neutralization tests;

D O I：

10.1097/00042560-199701010-00001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To examine the genetic and antigenic characteristics of HIV-1 in Indonesia, samples from 19 HIV-positive volunteers were studied. By a combination of PCR typing and DNA sequence analysis, 12 of the 19 volunteers were determined to be infected with HIV-1 clade B and seven with clade E. Six of the seven Indonesian clade E isolates were from volunteers associated with the Indonesian Military during a peacekeeping mission in Cambodia. Infectivity reduction neutralization assays showed that the Indonesian E viruses were effectively neutralized by Thailand clade E HIV-1 antisera but not by U.S. clade B antisera. The Indonesian clade B virus tested was neutralized by U.S. clade B antisera and not by the Thailand E antisera. Using a previously described serologic typing ELISA based on clade B and E V3 peptides, genetic clade was accurately determined in eight of eight sera tested. This is the first report of the genetic and antigenic analysis of HIV-1 isolates from Indonesia. The data indicate that at least two genetic and antigenic HIV-1 clades (clade E and B) circulate in Indonesia.

引用

页码：1 / 6

页数：6

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