Modeling the kinetics of acylation of insulin using a recursive method for solving the systems of coupled differential equations

被引：5

作者：

Grzybowski, BA ^{[1
]}

Anderson, JR ^{[1
]}

Colton, I ^{[1
]}

Brittain, ST ^{[1
]}

Shakhnovich, EI ^{[1
]}

Whitesides, GM ^{[1
]}

机构：

[1] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA

来源：

BIOPHYSICAL JOURNAL | 2000年 / 78卷 / 02期

关键词：

D O I：

10.1016/S0006-3495(00)76623-9

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

This paper describes a theoretical method for solving systems of coupled differential equations that describe the kinetics of complicated reaction networks in which a molecule having multiple reaction sites reacts irreversibly with multiple equivalents of a ligand (reagent). The members of the network differ in the number of equivalents of reagent that have reacted, and in the patterns of sites of reaction. A recursive algorithm generates series, asymptotic, and average solutions describing this kinetic scheme. This method was validated by successfully simulating the experimental data for the kinetics of acylation of insulin.

引用

页码：652 / 661

页数：10

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