Effect of single intracerebroventricular injection of α-interferon on monoamine concentrations in the rat brain

被引：93

作者：

Kamata, M ^{[1
]}

Higuchi, H ^{[1
]}

Yoshimoto, M ^{[1
]}

Yoshida, K ^{[1
]}

Shimizu, T ^{[1
]}

机构：

[1] Akita Univ, Sch Med, Dept Neuropsychiat, Akita 0108543, Japan

来源：

EUROPEAN NEUROPSYCHOPHARMACOLOGY | 2000年 / 10卷 / 02期

关键词：

alpha-interferon; noradrenaline; serotonin; side effect; rat brain;

D O I：

10.1016/S0924-977X(99)00067-X

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The effect of a single intracerebroventricular (i.c.v.) injection of alpha-IFN on levels of central monoamines and their metabolites in six brain regions (frontal cortex, striatum, hypothalamus, hippocampus, mid brain and medulla) of the rat was investigated. Wistar rats (n = 10) were decapitated 2 h after i.c.v. injection of alpha-IFN. The brain tissues were homogenized, and monoamine concentrations were measured by high-performance liquid chromatography with an electrochemical detector. The levels of 5-hydroxytryptamine (5-HT) were significantly reduced in the frontal cortex in a dose-dependent manner, and the levels of both 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) were reduced in the mid brain and the striatum. The levels of noradrenaline (NA) were also significantly reduced in a dose-dependent manner in the frontal cortex. Some neurophysiological changes that affect activity of the noradrenergic or/and the serotonergic neuron system may occur during IFN therapy. (C) 2000 Published by Elsevier Science B.V. All rights reserved.

引用

页码：129 / 132

页数：4

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