Ferritin for the clinician

被引：472

作者：

Knovich, Mary Ann ^{[1
]}

Storey, Jonathan A. ^{[1
]}

Coffman, Lan G. ^{[1
]}

Torti, Suzy V. ^{[1
]}

Torti, Frank M. ^{[1
]}

机构：

[1] Wake Forest Univ Hlth Sci, Sect Hematol & Oncol, Winston Salem, NC 27157 USA

来源：

BLOOD REVIEWS | 2009年 / 23卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Ferritin; Iron; STEM-CELL TRANSPLANTATION; RESTLESS LEGS SYNDROME; KALLIKREIN-KININ SYSTEM; HUMAN H-KININOGEN; IRON-OVERLOAD; SERUM FERRITIN; MAGNETIC-RESONANCE; HEREDITARY HEMOCHROMATOSIS; MYOCARDIAL-INFARCTION; NONINVASIVE MEASUREMENT;

D O I：

10.1016/j.blre.2008.08.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Ferritin, a major iron storage protein, is essential to iron homeostasis and is involved in a wide range of physiologic and pathologic processes. In clinical medicine, ferritin is predominantly utilized as a serum marker of total body iron stores. In cases of iron deficiency and overload, serum ferritin serves a critical role in both diagnosis and management. Elevated serum and tissue ferritin are linked to coronary artery disease, malignancy, and poor outcomes following stem cell transplantation. Ferritin is directly implicated in less common but potentially devastating human diseases including sideroblastic anemias, neurodegenerative disorders, and hemophagocytic syndrome. Additionally, recent research describes novel functions of ferritin independent of iron storage. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：95 / 104

页数：10

共 93 条

[1] Iron-overload-related disease in HFE hereditary hemochromatosis [J].

Allen, Katrina J. ;

Gurrin, Lyle C. ;

Constantine, Clare C. ;

Osborne, Nicholas J. ;

Delatycki, Martin B. ;

Nicoll, Amanda J. ;

McLaren, Christine E. ;

Bahlo, Melanie ;

Nisselle, Amy E. ;

Vulpe, Chris D. ;

Anderson, Gregory J. ;

Southey, Melissa C. ;

Giles, Graham G. ;

English, Dallas R. ;

Hopper, John L. ;

Olynyk, John K. ;

Powell, Lawrie W. ;

Gertig, Dorota M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (03) :221-230

[2] Frequent severe liver iron overload after stem cell transplantation and its possible association with invasive aspergillosis [J].

Altes, A ;

Remacha, AF ;

Sarda, P ;

Sancho, FJ ;

Sureda, A ;

Martino, R ;

Briones, J ;

Brunet, S ;

Canals, C ;

Sierra, J .

BONE MARROW TRANSPLANTATION, 2004, 34 (06) :505-509

[3] Iron overload might increase transplant-related mortality in haematopoietic stem cell transplantation [J].

Altès, A ;

Remacha, AF ;

Sureda, A ;

Martino, R ;

Briones, J ;

Canals, C ;

Brunet, S ;

Sierra, J ;

Gimferrer, E .

BONE MARROW TRANSPLANTATION, 2002, 29 (12) :987-989

[4] Early clinical impact of iron overload in stem cell transplantation. A prospective study [J].

Altes, Albert ;

Remacha, Angel Francisco ;

Sarda, Pilar ;

Baiget, Montserrat ;

Sureda, Anna ;

Martino, Rodrigo ;

Briones, Javier ;

Brunet, Salut ;

Canals, Carme ;

Sierra, Jorge .

ANNALS OF HEMATOLOGY, 2007, 86 (06) :443-447

[5] Hepatic iron metabolism [J].

Anderson, GJ ;

Frazer, DM .

SEMINARS IN LIVER DISEASE, 2005, 25 (04) :420-432

[6] Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload [J].

Anderson, LJ ;

Holden, S ;

Davis, B ;

Prescott, E ;

Charrier, CC ;

Bunce, NH ;

Firmin, DN ;

Wonke, B ;

Porter, J ;

Walker, JM ;

Pennell, DJ .

EUROPEAN HEART JOURNAL, 2001, 22 (23) :2171-2179

[7] Iron homeostasis [J].

Andrews, Nancy C. ;

Schmidt, Paul J. .

ANNUAL REVIEW OF PHYSIOLOGY, 2007, 69 :69-85

[8] Medical progress: Disorders of iron metabolism [J].

Andrews, NC .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (26) :1986-1995

[9] Understanding heme transport [J].

Andrews, NC .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (23) :2508-2509

[10]

[Anonymous], 2001, Pathology and Genetics: Tumours of Haematopoietic and Lymphoid Tissues

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