Multiple sclerosis:: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system

被引：210

作者：

Sorensen, TL ^{[1
]}

Trebst, C

Kivisäkk, P

Klaege, KL

Majmudar, A

Ravid, R

Lassmann, H

Olsen, DB

Strieter, RM

Ransohoff, RM

Sellebjerg, F

机构：

[1] Univ Copenhagen, Dept Neurol, MS Clin, Glostrup Hosp, Glostrup 2600, Denmark

[2] Cleveland Clin Fdn, Lerner Res Inst, Dept Neurosci, Cleveland, OH USA

[3] Netherlands Brain Bank, Amsterdam, Netherlands

[4] Univ Vienna, Inst Brain Res, Vienna, Austria

[5] Univ Calif Los Angeles, Div Pulm Med, Los Angeles, CA USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2002年 / 127卷 / 1-2期

关键词：

multiple sclerosis; CXCR3; CXCL10; central nervous system; inflammation; demyelination;

D O I：

10.1016/S0165-5728(02)00097-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T-cell accumulation in the central nervous system (CNS) is considered crucial to the pathogenesis of multiple sclerosis (MS). We found that the majority of T cells within the cerebrospinal fluid (CSF) compartment expressed the CXC chemokine receptor 3 (CXCR), independent of CNS inflammation. Quantitative immumohistochemistry revealed continuous accumulation of CXCR3+ T cells during MS lesion formation. The expression of one CXCR3 ligand, interferon (IFN)-gamma-inducible protein of 10 kDa (IP-10)/CXC chemokine ligand (CXCL) 10 was elevated in MS CSF, spatially associated with demyelination in CNS tissue sections and correlated tightly with CXCR3 expression. These data Suggest a critical role for CXCL10 and CXCR3 in the accumulation of T cells in the CNS of MS patients. (C) 2002 Elsevier Science B.V.. All rights reserved.

引用

页码：59 / 68

页数：10

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