Inhibitory effect of dehydroevodiamine and evodiamine on nitric oxide production in cultured murine macrophages

被引：83

作者：

Chiou, WF

Sung, YJ

Liao, JF

Shum, AYC

Chen, CF

机构：

[1] NATL RES INST CHINESE MED,TAIPEI 11221,TAIWAN

[2] NATL YANG MING UNIV,INST & DEPT ANAT,TAIPEI 112,TAIWAN

[3] NATL YANG MING UNIV,DEPT PHARMACOL,TAIPEI 112,TAIWAN

来源：

JOURNAL OF NATURAL PRODUCTS | 1997年 / 60卷 / 07期

关键词：

D O I：

10.1021/np960495z

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Possible antiinflammatory effects of dehydroevodiamine (1) and evodiamine (2) were examined by assessing their effects an NO production in the murine macrophage-like cell line RAW 264.7. The results indicated that both 1 and 2 inhibited the IFN-gamma/LPS-stimulated NO production in a concentration-dependent manner. However, 1 appeared to inhibit NO production by interfering not only with the priming signal initiated by IFN-gamma but also with iNOS protein synthesis, while 2 affected the former only.

引用

页码：708 / 711

页数：4

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