Thrombolysis of cerebral clot embolism in rat:: effect of treatment delay

被引：29

作者：

Brinker, G ^{[1
]}

Franke, C ^{[1
]}

Hoehn, M ^{[1
]}

Uhlenküken, U ^{[1
]}

Hossmann, KA ^{[1
]}

机构：

[1] Max Planck Inst Neurol Res, D-50931 Cologne, Germany

来源：

NEUROREPORT | 1999年 / 10卷 / 16期

关键词：

ADC; clot embolism; diffusion-weighted imaging; rt-PA; thrombolysis;

D O I：

10.1097/00001756-199911080-00004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

RATS submitted to focal cerebral ischemia by middle cerebral artery clot embolism were treated with recombinant tissue plasminogen activator (rt-PA) at increasing delays (1.5, 3 and 4.5 h) after the onset of ischemia. Treatment efficacy was evaluated by NMR-imaging of the apparent diffusion coefficient of water (ADC). In untreated animals the size of the ADC-detectable lesion gradually increased after clot embolism, expanding over 8 h to 174 +/- 17% of the volume visible at 30 min. Thrombolysis initiated 1.5 h after embolism did not reverse the ischemic lesion but reduced its growth to 113 +/- 19% (P < 0.05). Lesion size increased to 135 +/- 14% after 3 h (NS) and to 214 +/- 35% after 4.5 h delay (NS). Thrombolysis with rt-PA attenuates infarct expansion but does not reverse ischemic injury. NeuroReport 10:3269-3272 (C) 1999 Lippincott Williams & Wilkins.

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收藏

页码：3269 / 3272

页数：4

相关论文

共 25 条

[1] Activation of complement by tissue plasminogen activator, but not acute cerebral ischemia, in a rabbit model of thromboembolic stroke [J].

Bednar, MM ;

Gross, CE ;

Russell, SR ;

Short, D ;

Giclas, PC .

JOURNAL OF NEUROSURGERY, 1997, 86 (01) :139-142

[2] MONOCLONAL-ANTIBODIES PREVENTING LEUKOCYTE ACTIVATION REDUCE EXPERIMENTAL NEUROLOGIC INJURY AND ENHANCE EFFICACY OF THROMBOLYTIC THERAPY [J].

BOWES, MP ;

ROTHLEIN, R ;

FAGAN, SC ;

ZIVIN, JA .

NEUROLOGY, 1995, 45 (04) :815-819

[3] Acute hypertension, but not thrombolysis, increases the incidence and severity of hemorrhagic transformation following experimental stroke in rabbits [J].

Bowes, MP ;

Zivin, JA ;

Thomas, GR ;

Thibodeaux, H ;

Fagan, SC .

EXPERIMENTAL NEUROLOGY, 1996, 141 (01) :40-46

[4] Brain hemorrhages after rt-PA treatment of embolic stroke in spontaneously hypertensive rats [J].

Brinker, G ;

Pillekamp, F ;

Hossmann, KA .

NEUROREPORT, 1999, 10 (09) :1943-1946

[5] Reperfusion after thrombolytic therapy of embolic stroke in the rat:: Magnetic resonance and biochemical imaging [J].

Busch, E ;

Krüger, K ;

Allegrini, PR ;

Kerskens, CM ;

Gyngell, ML ;

Hoehn-Berlage, M ;

Hossmann, KA .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1998, 18 (04) :407-418

[6] Improved model of thromboembolic stroke and rt-PA induced reperfusion in the rat [J].

Busch, E ;

Krüger, K ;

Hossmann, KA .

BRAIN RESEARCH, 1997, 778 (01) :16-24

[7] Evolution of acute focal cerebral ischaemia in rats observed by localized H-1 MRS, diffusion-weighted MRI, and electrophysiological monitoring [J].

Gyngell, ML ;

Busch, E ;

Schmitz, B ;

Kohno, K ;

Back, T ;

HoehnBerlage, M ;

Hossmann, KA .

NMR IN BIOMEDICINE, 1995, 8 (05) :206-214

[8]

HACKE W, 1995, JAMA-J AM MED ASSOC, V274, P1017, DOI 10.1001/jama.274.13.1017

[9] Thrombolytic therapy in acute ischaemic stroke: The jury needs more evidence [J].

Hankey, GJ .

MEDICAL JOURNAL OF AUSTRALIA, 1997, 166 (08) :419-422

[10] EVOLUTION OF REGIONAL CHANGES IN APPARENT DIFFUSION-COEFFICIENT DURING FOCAL ISCHEMIA OF RAT-BRAIN - THE RELATIONSHIP OF QUANTITATIVE DIFFUSION NMR IMAGING TO REDUCTION IN CEREBRAL BLOOD-FLOW AND METABOLIC DISTURBANCES [J].

HOEHNBERLAGE, M ;

NORRIS, DG ;

KOHNO, K ;

MIES, G ;

LEIBFRITZ, D ;

HOSSMANN, KA .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1995, 15 (06) :1002-1011