Targeting eNOS for stroke protection

被引:219
作者
Endres, M
Laufs, U
Liao, JK
Moskowitz, MA
机构
[1] Humboldt Univ, Charite Hosp, Dept Neurol, D-10117 Berlin, Germany
[2] Saarland Univ Hosp, Dept Med 3, D-66421 Homburg, Germany
[3] Brigham & Womens Hosp, Cambridge, MA 02139 USA
[4] Harvard Univ, Sch Med, Cambridge, MA 02139 USA
[5] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Stroke & Neurovasc Regulat Lab, Charlestown, MA 02129 USA
关键词
D O I
10.1016/j.tins.2004.03.009
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Nitric oxide (NO) generated by endothelial NO synthase (eNOS) plays a crucial role in vascular function and homeostasis. NO possesses vasodilatory, anti-inflammatory, antithrombotic and antiproliferative properties. Augmentation of NO production increases cerebral blood flow, which can lead to neuroprotection during brain ischaemia. Several modalities that upregulate eNOS expression and/or activity have recently been identified, including HMG-CoA reductase inhibitors (statins), steroid hormones, nutrients and physical activity. They all increase NO bioavailability, leading to enhanced cerebral blood flow and protection from ischaemic stroke. Thus, therapeutic modalities that target eNOS not only serve as preventive measures to reduce stroke incidence but also could represent novel treatment strategies for reducing brain injury during cerebral ischaemia.
引用
收藏
页码:283 / 289
页数:7
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