Is atherosclerosis fundamental to human aging? Lessons from ancient mummies

被引：22

作者：

Clarke, Emily M. ^{[1
]}

Thompson, Randall C. ^{[2
,3
]}

Allam, Adel H. ^{[4
]}

Wann, L. Samuel ^{[5
]}

Lombardi, Guido P. ^{[6
]}

Sutherland, M. Linda ^{[7
]}

Sutherland, James D. ^{[8
]}

Cox, Samantha L. ^{[9
]}

Soliman, Muhammad Al-Tohamy ^{[10
]}

Abd El-Maksoud, Gomaa ^{[11
]}

Badr, Ibrahem ^{[12
]}

Miyamoto, Michael I. ^{[13
]}

Frohlich, Bruno ^{[14
]}

El-Din, Abdel-Halim Nur ^{[15
]}

Stewart, Alexandre F. R. ^{[16
]}

Narula, Jagat ^{[17
]}

Zink, Albert R. ^{[18
]}

Finch, Caleb E. ^{[19
]}

Michalik, David E. ^{[20
]}

Thomas, Gregory S. ^{[21
]}

机构：

[1] Univ Calif Los Angeles, Los Angeles, CA USA

[2] St Lukes Mid Amer Heart Inst, Kansas City, MO USA

[3] Univ Missouri, Sch Med, Kansas City, MO 64108 USA

[4] Al Azhar Med Sch, Cairo, Egypt

[5] Columbia St Marys Healthcare, Milwaukee, WI USA

[6] Univ Peruana Cayetano Heredia, Lab Paleopatol, Catedra Pedro Weiss, Lima, Peru

[7] Newport Diagnost Ctr, Newport Beach, CA USA

[8] Saddleback Mem, Laguna Hills, CA USA

[9] Univ Cambridge, Cambridge, England

[10] Natl Res Ctr, Giza, Egypt

[11] Cairo Univ, Cairo, Egypt

[12] Inst Restorat, Alexandria, Egypt

[13] Miss Internal Med Grp, Mission Viejo, CA USA

[14] Smithsonian Inst, Natl Museum Nat Hist, Washington, DC 20560 USA

[15] Univ Sci & Technol, 6TH Of October City, Egypt

[16] Univ Ottawa, Inst Heart, Ottawa, ON, Canada

[17] Mt Sinai, New York, NY USA

[18] European Acad, Inst Mummies & Iceman, Bolzano, Italy

[19] Univ So Calif, Los Angeles, CA USA

[20] Miller Childrens Hosp, Long Beach, CA USA

[21] Univ Calif Irvine, Irvine, CA USA

来源：

JOURNAL OF CARDIOLOGY | 2014年 / 63卷 / 5-6期

基金：

美国人文基金会;

关键词：

Mummies; Atherosclerosis; Aging; Paleopathology; Coronary artery disease; CORONARY-HEART-DISEASE; EGYPTIAN MUMMIES; CARDIOVASCULAR-DISEASE; RISK; INFLAMMATION; INFLUENZA; INFECTION; COMPLEX; LESIONS; HORUS;

D O I：

10.1016/j.jjcc.2013.12.012

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Case reports from Johan Czermak, Marc Ruffer, and others a century or more ago demonstrated ancient Egyptians had atherosclerosis three millennia ago. The Horus study team extended their findings, demonstrating that atherosclerosis was prevalent among 76 ancient Egyptian mummies and among 61 mummies from each of the ancient cultures of Peru, the American Southwest, and the Aleutian Islands. These findings challenge the assumption that atherosclerosis is a modern disease caused by present day risk factors. An extensive autopsy of an ancient Egyptian teenage male weaver named Nakht found that he was infected with four parasites: Schistosoma haematobium, Taenia species, Trichinella spiralis, and Plasmodium falciparum. Modern day patients with chronic inflammatory disease such as rheumatoid arthritis, systemic lupus erythematosus, and human immunodeficiency virus experience premature atherosclerosis. Could the burden of chronic inflammatory disease have been a risk factor for atherosclerosis in these ancient cultures? The prevalence of atherosclerosis in four diverse ancient cultures is consistent with atherosclerosis being fundamental to aging. The impact of risk factors in modern times, and potentially in ancient times, suggests a strong gene-environmental interplay: human genes provide a vulnerability to atherosclerosis, the environment determines when and if atherosclerosis becomes manifest clinically. (C) 2014 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.

引用

页码：329 / 334

页数：6

共 51 条

[1] Atherosclerotic cardiovascular disease in Egyptian women: 1570 BCE-2011 CE [J].

Abdelfattah, Alia ;

Allam, Adel H. ;

Wann, Samuel ;

Thompson, Randall C. ;

Abdel-Maksoud, Goma ;

Badr, Ibrahem ;

Amer, Hany Abdel Rahman ;

el-Din, Abd el-Halim Nur ;

Finch, Caleb E. ;

Miyamoto, Michael I. ;

Sutherland, Linda ;

Sutherland, James D. ;

Thomas, Gregory S. .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2013, 167 (02) :570-574

[2] Atherosclerosis in Ancient Egyptian Mummies The Horus Study [J].

Allam, Adel H. ;

Thompson, Randall C. ;

Wann, L. Samuel ;

Miyamoto, Michael I. ;

El-Din, Abd El-Halim Nur ;

Abd El-Maksoud, Gomaa ;

Soliman, Muhammad Al-Tohamy ;

Badr, Ibrahem ;

Amer, Hany Abd El-Rahman ;

Sutherland, M. Linda ;

Sutherland, James D. ;

Thomas, Gregory S. .

JACC-CARDIOVASCULAR IMAGING, 2011, 4 (04) :315-327

[3]

Allam Adel H, 2010, Am Heart Hosp J, V8, P10

[4] Computed Tomographic Assessment of Atherosclerosis in Ancient Egyptian Mummies [J].

Allam, Adel H. ;

Thompson, Randall C. ;

Wann, L. Samuel ;

Miyamoto, Michael I. ;

Thomas, Gregory S. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2009, 302 (19) :2091-2094

[5]

[Anonymous], 1998, MUMMIES DIS ANCIENT

[6]

[Anonymous], 2000, CONVERSATIONS MUMMIE

[7]

Antunez de Mayolo S., 1981, Nutricion en el antiguo Peru

[8] A Comparison of Vascular Effects from Complex and Individual Air Pollutants Indicates a Role for Monoxide Gases and Volatile Hydrocarbons [J].

Campen, Matthew J. ;

Lund, Amie K. ;

Doyle-Eisele, Melanie L. ;

McDonald, Jacob D. ;

Knuckles, Travis L. ;

Rohr, Annette C. ;

Knipping, Eladio M. ;

Mauderly, Joe L. .

ENVIRONMENTAL HEALTH PERSPECTIVES, 2010, 118 (07) :921-927

[9]

Chan L., 1994, Cardiol Rev, V2, P130, DOI DOI 10.1097/00045415-199405000-00003

[10]

Chockalingam ABI., 1999, Impending Global Pandemic of Cardiovascular Diseases: Challenges and Opportunities for the Prevention and Control of Cardiovascular Diseases in Developing Countries and Economies in Transition

← 1 2 3 4 5 6 →