H-1-magnetic resonance spectroscopy in obsessive-compulsive disorder: Evidence for neuronal loss in the cingulate gyrus and the right striatum

被引：117

作者：

Ebert, D ^{[1
]}

Speck, O ^{[1
]}

Konig, A ^{[1
]}

Berger, M ^{[1
]}

Hennig, J ^{[1
]}

Hohagen, F ^{[1
]}

机构：

[1] UNIV FREIBURG,DEPT NEURORADIOL,FREIBURG,GERMANY

来源：

PSYCHIATRY RESEARCH-NEUROIMAGING | 1997年 / 74卷 / 03期

关键词：

nuclear magnetic resonance tomography; anxiety disorders; N-acetyl-aspartate; brain imaging;

D O I：

10.1016/S0925-4927(97)00016-4

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We compared 12 patients with obsessive-compulsive disorder (OCD) and six control subjects by H-1-magnetic resonance spectroscopy. Significantly lower relative N-acetyl-aspartate (NAA) levels were found in the right striatum of OCD patients, as well as a decrease of anterior cingulate NAA that correlated with severity of illness. Age and sex were correlated to striatal NAA levels. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：173 / 176

页数：4

共 11 条

[1]

[Anonymous], 1994, Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV), V4th

[2]

Baxter Lewis R. Jr., 1995, P1287

[3] N-ACETYL-L-ASPARTIC ACID - A LITERATURE-REVIEW OF A COMPOUND PROMINENT IN H-1-NMR SPECTROSCOPIC STUDIES OF BRAIN [J].