Galectins and cancer

被引：298

作者：

Danguy, A ^{[1
]}

Camby, I ^{[1
]}

Kiss, R ^{[1
]}

机构：

[1] Free Univ Brussels, Fac Med, Lab Histopathol, B-1070 Brussels, Belgium

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS | 2002年 / 1572卷 / 2-3期

关键词：

galectin; cancer; metastasis;

D O I：

10.1016/S0304-4165(02)00315-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The galectins are a family of proteins that are distributed widely in all living organisms. All of them share galactose-specificity. At present, 14 members of the family are characterized in mammals. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, RNA splicing, and tumor metastasis. Although efforts have mostly focused on the possible function of galectins in tumor development and invasiveness, their precise role in this field is still debated. This review discusses the recent way in which the expression of galectins and galectin-binding sites may affect the behavior of a variety of human neoplastic tissues. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：285 / 293

页数：9

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