Age-related change of plasma extracellular-superoxide dismutase

被引:30
作者
Adachi, T
Wang, J
Wang, XL
机构
[1] Gifu Pharmaceut Univ, Lab Clin Pharmaceut, Gifu 5028585, Japan
[2] Westmead Hosp, Dept Obstet & Gynaecol, Sydney, NSW 2145, Australia
[3] Univ New S Wales, Prince Wales Hosp, Dept Cardiovasc Med, Sydney, NSW, Australia
基金
英国医学研究理事会;
关键词
extracellular-superoxide dismutase; plasma; antioxidant capacity;
D O I
10.1016/S0009-8981(99)00187-4
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Extracellular-superoxide dismutase (EC-SOD) is a secretory protein that is the major SOD isozyme in extracellular fluids. Plasma EC-SOD mass,concentrations in individuals were distributed in two discrete groups with the rare group (2.9%) having a variant of the enzyme with about 15-fold higher plasma levels. The EC-SOD level of-the common phenotype in children/ youths was significantly higher than that in their parents, and decreased with age, with an average decrease of about 2% per year to age 20. On the other hand, the parents' EC-SOD increased slightly with age. The cord EC-SOD level was the lowest. We observed no significant age-dependent changes in mass concentrations of copper- and zinc-containing SOD (Cu,Zn-SOD) or manganese-containing SOD (Mn-SOD). The total SOD activity in children/youths was significantly higher than that in parents and decreased with age. Three SOD isozymes function together in a complementary manner as a consequence of different cellular and subcellular distributions. However, the results suggest that the changes in EC-SOD levels may be the most sensitive biomarker for age-related changes in the antioxidant capacity. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:169 / 178
页数:10
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