TEM-28 from an Escherichia coli clinical isolate is a member of the his-164 family of TEM-1 extended-spectrum beta-lactamases

被引：23

作者：

Bradford, PA

Jacobus, NV

Bhachech, N

Bush, K

机构：

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1996年 / 40卷 / 01期

关键词：

D O I：

10.1128/AAC.40.1.260

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

TEM-28 (pl 6.1), expressed by an Escherichia coli clinical isolate, is a novel beta-lactamase which hgdrolyzed ceftazidime, cefotaxime, and aztreonam with rates of 2.5, 1.1, and 5.6, respectively, relative to that for benzylpenicillin (100). The nucleotide sequence of bla(TEM-28) differed from that of bla(TEM-1) by two base changes, resulting in amino acid substitutions of Arg-164 to His and Glu-240 to Lys.

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页码：260 / 262

页数：3

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