A mammalian capacitative calcium entry channel homologous to Drosophila TRP and TRPL

被引：251

作者：

Philipp, S ^{[1
]}

Cavalie, A ^{[1
]}

Freichel, M ^{[1
]}

Wissenbach, U ^{[1
]}

Zimmer, S ^{[1
]}

Trost, C ^{[1
]}

Marquart, A ^{[1
]}

Murakami, M ^{[1
]}

Flockerzi, V ^{[1
]}

机构：

[1] UNIV HEIDELBERG,INST PHARMAKOL,D-69120 HEIDELBERG,GERMANY

来源：

EMBO JOURNAL | 1996年 / 15卷 / 22期

关键词：

calcium signalling; calcium spiking; capacitative calcium entry; InsP(3) signalling; store depletion;

D O I：

10.1002/j.1460-2075.1996.tb01004.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Intracellular Ca2+ signalling evoked by Ca2+ mobilizing agonists, like angiotensin II in the adrenal gland, involves the activation of inositol(1,4,5)trisphosphate(InsP(3))-mediated Ca2+ release from internal stores followed by activation of a Ca2+ influx termed capacitative calcium entry, Here we report the amino acid sequence of a functional capacitative Ca2+ entry (CCE) channel that supports inward Ca2+ currents in the range of the cell resting potential. The expressed CCE channel opens upon depletion of Ca2+ stores by InsP(3) or thapsigargin, suggesting that the newly identified channel supports the CCE coupled to InsP(3) signalling.

引用

页码：6166 / 6171

页数：6

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