Association study between iron-related genes polymorphisms and Parkinson's disease

被引：96

作者：

Borie, C

Gasparini, F

Verpillat, P

Bonnet, AM

Agid, Y

Hetet, G

Brice, A

Dürr, A

Grandchamp, B

机构：

[1] Fac Med Bichat, Assoc Claude Bernard, INSERM U409, F-75870 Paris 18, France

[2] Hop La Pitie Salpetriere, INSERM U289, Paris, France

[3] CHU Xavier, Dept Biostat & Epidemiol, Paris, France

来源：

JOURNAL OF NEUROLOGY | 2002年 / 249卷 / 07期

关键词：

Parkinson; iron; polymorphism; transferrin; genetics;

D O I：

10.1007/s00415-002-0704-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We have conducted a case-control study in order to test for an association between 8 intragenic polymorphisms of 5 iron-related genes (transferrin, transferrin receptor I, HFE, frataxin and lactoferrin) and Parkinson disease. Comparison of genotypes and allele frequencies did not differ significantly between cases and controls for all studied polymorphisms except the G258S transferrin polymorphism, for which a higher frequency of the G allele was found among cases (p=0.033), particularly among, cases with onset older than 60 (p=0.0017) and with negative family history (p=0.022). This finding suggests that genetic variations in the control of iron metabolism may contribute to the pathogenesis of the disease.

引用

页码：801 / 804

页数：4

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