Solid-phase synthesis and antibacterial activity of hydroxycinnamic acid amides and analogues against methicillin-resistant Staphylococcus aureus and vancomycin-resistant S-aureus

被引：27

作者：

Yingyongnarongkul, Boon-ek ^{[1
]}

Apiratikul, Nuttapon

Aroonrerk, Nuntana

Suksamrarn, Apichart

机构：

[1] Ramkhamhang Univ, Fac Sci, Dept Chem, Bangkok 10240, Thailand

[2] Srinakharinwirot Univ, Fac Dent, Dept Stomatol, Bangkok 10110, Thailand

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 22期

关键词：

hydroxycinnamic acid amides; solid-phase synthesis; antibacterial activity; MRSA; VRSA;

D O I：

10.1016/j.bmcl.2006.08.062

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A library of hydroxycinnamic acid amides (HCAAs) and analogues were synthesized using solid-phase synthesis technique. These compounds were screened for antibacterial against methicillin-resistant Staphylococcus aureus (MRSA) (11 strains) and vancomycin-resistant S. aureus (VRSA) (4 strains). Dihydrocaffeoyl analogues showed activity against VRSA which were better than the reference drugs, vancomycin and oxacillin. These compounds also exhibited antibacterial activity against MRSA, which were more potent than oxacillin. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：5870 / 5873

页数：4

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