Mitogenic action of LPA in prostate

被引：77

作者：

Daaka, Y

机构：

[1] Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Dept Pharmacol Canc Biol, Durham, NC 27710 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2002年 / 1582卷 / 1-3期

关键词：

LPA; EDG; MAP kinase; cell proliferation; prostate cancer;

D O I：

10.1016/S1388-1981(02)00180-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The lipid growth factor lysophosphatidic acid (LPA) elicits multiple cellular responses, including cell growth and survival. LPA acts upon target cells by activating its cognate receptors, which belong to the G protein-coupled endothelial differentiation gene (EDG) family. To date, three known LPA receptors, termed LPA1, LPA2 and LPA3, have been molecularly characterized and cloned. Here, we review recent data describing the molecular steps involved in the LPA receptor-mediated activation of mitogenic extracellular signal-regulated kinase (ERK) pathway in prostate cancer. Induction of ERK by LPA proceeds via Gbetagamma-dependent activation of tyrosine kinases, including the epidermal growth factor (EGF) receptor and c-Src. Further, LPA-induced ERK activation involves matrix metalloproteinases (MMPs), which cause the release of active EGFR ligands. Finally, we present data demonstrating a correlation between the mitogenic effects of LPA and expression of the lp(A1) gene in the prostate cancer cells. (C) 2002 Elsevier Science B.V. All rights reserved.

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页码：265 / 269

页数：5

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