Neural immunoregulation: emerging roles for nerves in immune homeostasis and disease

被引：161

作者：

Downing, JEG

Miyan, JA

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Neuroendocrinol, London W6 8RF, England

[2] Univ Manchester, Inst Sci & Technol, Dept Biomol Sci, Manchester M60 1QD, Lancs, England

来源：

IMMUNOLOGY TODAY | 2000年 / 21卷 / 06期

关键词：

D O I：

10.1016/S0167-5699(00)01635-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this review, James Downing and Jaleel Miyan outline emerging evidence for neural mechanisms that contribute to specific categories of host defence. Involvement of direct innervation in the adaptive control of immunological responses complements an established view of neuroendocrine-immune modulation. The challenge remains to understand the integrative and homeostatic functions of 'hardwiring' of peripheral immune effector sites, its bearing on disorder and potential for therapeutic modification.

引用

收藏

页码：281 / 289

页数：9

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