Coincidence detection and changes of synaptic efficacy in spiny stellate neurons in vat barrel cortex

被引：215

作者：

Egger, V ^{[1
]}

Feldmeyer, D ^{[1
]}

Sakmann, B ^{[1
]}

机构：

[1] Max Planck Inst Med Forsch, Abt Zellphysiol, D-69120 Heidelberg, Germany

来源：

NATURE NEUROSCIENCE | 1999年 / 2卷 / 12期

关键词：

D O I：

10.1038/16026

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Paired whole-cell voltage recordings were made from synaptically connected spiny stellate neurons in layer 4 of the barrel field in young (P14) rat somatosensory cortex. When postsynaptic action potentials (APs) followed each of 5 presynaptic APs in a 10- or 20-Hz train by less than 25 ms, subsequent unitary EPSP amplitudes were persistently reduced. Induction of long-term depression (LTD) depended on activation of group II metabotropic glutamate receptors, but not on NMDA or AMPA receptors. Reducing postsynaptic increases in intracellular calcium ([Ca2+](i)) by intracellular loading with a fast- (BAPTA) or a slow- (EGTA) acting Ca2+ buffer blocked synaptic depression. Analysis of EPSP failures suggested mediation of LTD by a reduction in release probability. We propose a mechanism by which coincident activity results in long-lasting reduction of synaptic efficacy between synaptically connected neurons.

引用

页码：1098 / 1105

页数：8

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