Protein tyrosine phosphatases in the human genome

被引：1565

作者：

Alonso, A

Sasin, J

Bottini, N

Friedberg, I

Friedberg, I

Osterman, A

Godzik, A

Hunter, T

Dixon, J

Mustelin, T

机构：

[1] Burnham Inst, Program Signal Transduct, La Jolla, CA 92037 USA

[2] Burnham Inst, Program Bioinformat, La Jolla, CA 92037 USA

[3] Salk Inst Biol Studies, Mol & Cell Biol Lab, La Jolla, CA 92037 USA

[4] Univ Calif San Diego, Sch Med, Dept Pharmacol, La Jolla, CA 92093 USA

来源：

CELL | 2004年 / 117卷 / 06期

关键词：

D O I：

10.1016/j.cell.2004.05.018

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tyrosine phosphorylation is catalyzed by protein tyrosine kinases, which are represented by 90 genes in the human genome. Here, we present the set of 107 genes in the human genome that encode members of the four protein tyrosine phosphatase (PTP) families. The four families of PTPases, their substrates, structure, function, regulation, and the role of these enzymes in human disease will be discussed.

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页码：699 / 711

页数：13

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