The receptor for Interleukin-17E is induced by Th2 cytokines in antigen-presenting cells

被引：51

作者：

Gratchev, A ^{[1
]}

Kzhyshkowska, J ^{[1
]}

Duperrier, K ^{[1
]}

Utikal, J ^{[1
]}

Velten, FW ^{[1
]}

Goerdt, S ^{[1
]}

机构：

[1] Univ Heidelberg, Univ Med Ctr Mannheim, Dept Dermatol, D-6800 Mannheim, Germany

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 2004年 / 60卷 / 03期

关键词：

D O I：

10.1111/j.0300-9475.2004.01443.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin-17E (IL-17E) (IL-25) is a recently identified cytokine capable to induce Th2-associated cytokine production (IL-5 and IL-13) and T helper 2 (Th2)-type pathologies in animal models. The IL-17E-responsive cell population in vivo was described to be a further uncharacterized non-T-, non-B-splenic accessory cell. Despite the identification of IL-17BR as the receptor for IL-17E, the cell population expressing IL-17BR has hitherto not been identified. Here, we show that human monocyte-derived Th2-skewed antigen-presenting cells (APC2) express membrane-bound and soluble forms of IL-17BR on the mRNA and protein level upon stimulation with IL-4, IL-10, IL-13 or transforming growth factor-betain vitro. These results indicate that IL-17BR-expressing APC2s may mediate the development of the IL-17E-mediated immunological reaction patterns observed in vivo.

引用

页码：233 / 237

页数：5

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