Rho GTPases in cell biology

被引：3898

作者：

Etienne-Manneville, S

Hall, A

机构：

[1] UCL, MRC, Mol Cell Biol Lab, London WC1E 6BT, England

[2] UCL, Canc Res UK Incogene & Signaal Transduct Grp, Cell Biol Unit, London WC1E 6BT, England

[3] UCL, Dept Biochem & Mol Biol, London WC1E 6BT, England

来源：

NATURE | 2002年 / 420卷 / 6916期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/nature01148

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Rho GTPases are molecular switches that control a wide variety of signal transduction pathways in all eukaryotic cells. They are known principally for their pivotal role in regulating the actin cytoskeleton, but their ability to influence cell polarity, microtubule dynamics, membrane transport pathways and transcription factor activity is probably just as significant. Underlying this biological complexity is a simple biochemical idea, namely that by switching on a single GTPase, several distinct signalling pathways can be coordinately activated. With spatial and temporal activation of multiple switches factored in, it is not surprising to find Rho GTPases having such a prominent role in eukaryotic cell biology.

引用

页码：629 / 635

页数：7

共 77 条

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