Human mannose-binding lectin in immunity: Friend, foe, or both?

被引：93

作者：

Casanova, JL

Abel, L

机构：

[1] Univ Paris 05, Lab Human Genet Infect Dis, INSERM,U550, Necker Med Sch, F-75015 Paris, France

[2] Necker Enfants Malad Hosp, Pediat Hematol Immunol Unit, F-75015 Paris, France

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2004年 / 199卷 / 10期

关键词：

D O I：

10.1084/jem.20040537

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human mannose-binding lectin (MBL) recognizes a wide range of microorganisms and triggers the most ancient pathway of complement activation. However, similar to5% of individuals lack functional serum MBL and have not been found to be prone to severe infections in prospective studies. These data suggest that human MBL is largely redundant for protective immunity and may even have been subject to counter selection because of a deleterious impact.

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页码：1295 / 1299

页数：5

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