Behavioral analysis of olfactory coding and computation in rodents

被引:20
作者
Mainen, Zachary F. [1 ]
机构
[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
关键词
D O I
10.1016/j.conb.2006.06.003
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Behavioral analysis is essential to understand how the olfactory system transforms chemosensory signals into information that can be used to guide actions. Recent studies in rodents have begun to address the behavioral relevance of putative olfactory codes and computations including spatial maps, oscillatory synchrony, and evolving temporal codes. To date, these studies have failed to find support for a role of any of these mechanisms in odor discrimination. Progress calls. for experiments using precise psychophysical methods in conjunction with neural recording or perturbation, in addition to ethologically minded exploration of more complex forms of odor-guided behavior.
引用
收藏
页码:429 / 434
页数:6
相关论文
共 59 条
[1]   Maintaining accuracy at the expense of speed: Stimulus similarity defines odor discrimination time in mice [J].
Abraham, NM ;
Spors, H ;
Carleton, A ;
Margrie, TW ;
Kuner, T ;
Schaefer, AT .
NEURON, 2004, 44 (05) :865-876
[2]   THE ELECTRICAL ACTIVITY OF THE MAMMALIAN OLFACTORY BULB [J].
ADRIAN, ED .
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1950, 2 (04) :377-388
[3]   An integrative theory of locus coeruleus-norepinephrine function: Adaptive gain and optimal performance [J].
Aston-Jones, G ;
Cohen, JD .
ANNUAL REVIEW OF NEUROSCIENCE, 2005, 28 :403-450
[4]   Performance of mice in an automated olfactometer: Odor detection, discrimination and odor memory [J].
Bodyak, N ;
Slotnick, B .
CHEMICAL SENSES, 1999, 24 (06) :637-645
[5]  
BUCINIC D, 2006, J NEUROPHYSIOL, V95, P1881
[6]   A NOVEL MULTIGENE FAMILY MAY ENCODE ODORANT RECEPTORS - A MOLECULAR-BASIS FOR ODOR RECOGNITION [J].
BUCK, L ;
AXEL, R .
CELL, 1991, 65 (01) :175-187
[7]   Respiratory modulation of olfactory neurons in the rodent brain [J].
Buonviso, N ;
Amat, C ;
Litaudon, P .
CHEMICAL SENSES, 2006, 31 (02) :145-154
[8]  
DAVIS JL, 1991, OLFACTON MODEL SYSTE
[9]  
Dittman AH, 1996, J EXP BIOL, V199, P83
[10]   High-frequency oscillations are not necessary for simple olfactory discriminations in young rats [J].
Fletcher, ML ;
Smith, AM ;
Best, AR ;
Wilson, DA .
JOURNAL OF NEUROSCIENCE, 2005, 25 (04) :792-798