Pentylenetetrazol-induced seizures and kindling: changes in free fatty acids, superoxide dismutase, and glutathione peroxidase activity

被引：71

作者：

Erakovic, V

Zupan, G

Varljen, J

Simonic, A

机构：

[1] Univ Rijeka, Sch Med, Dept Pharmacol, Rijeka, Croatia

[2] Univ Rijeka, Sch Med, Dept Chem & Biochem, Rijeka, Croatia

来源：

NEUROCHEMISTRY INTERNATIONAL | 2003年 / 42卷 / 02期

关键词：

free fatty acids; glutathione peroxidase; pentylenetetrazol kindling; rat; superoxide dismutase;

D O I：

10.1016/S0197-0186(02)00070-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The whole brain free fatty acid (FFA) level, as well as the activities of superoxide dismutase (SOD) and glutathione peroxidase (GPX) were determined in the frontal cortex, cerebellum, hippocampus, and pons-medulla region of the single pentylenctetrazol (PZT)-treated and PZT-kindled Hannover-Wistar rats. PZT administration in the convulsive dose caused significant increase of the brain FFA content. Decreased SOD activity was detected in the frontal cortex of PZT-kindled rats, whereas decreased GPX activity was found in the frontal cortex and cerebellum of all treated rats, as well as in the hippocampus and pons-medulla of PZT-kindled rats. Kindling caused distinctive change of antioxidative defense in the frontal cortex, hippocampus, and pons-medulla region. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：173 / 178

页数：6

共 29 条

[1] Inhibition of glutathione depletion by retinoic acid and tocopherol protects cultured neurons from staurosporine-induced oxidative stress and apoptosis [J].