Neutrophil responses to CRP are not dependent on polymorphism of human FcγRIIA (R131H)

被引:5
作者
Rodríguez, JA [1 ]
Bodman-Smith, KB [1 ]
Raynes, JG [1 ]
机构
[1] Univ London London Sch Hyg & Trop Med, Dept Infect & Trop Dis, Immunol Unit, London WC1E 7HT, England
关键词
CRP; Fc receptor; neutrophils; Streptococcus pneumoniae; reactive oxygen; phagocytosis; interleukin; 8;
D O I
10.1111/j.1365-2249.2004.02603.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
IgG2a mediated in vitro phagocytosis is less effective for individuals homozygous for Fcgamma RIIaR131 allele and such individuals are also more susceptible to certain infections. It has been reported that CRP binds to Fcgamma RIIaR131 but not Fcgamma RIIaH131 and since Fcgamma RIIa is also a major Fc receptor on neutrophils it would be expected that normal healthy donors who did not have at least one copy of Fcgamma RIIaR131 would not respond to CRP. We examined responses reported to be dependent on FcgammaRIIa but no difference between groups was observed in CRP mediated phagocytosis of S. pneumoniae, reactive oxygen production, or IL-8 synthesis. This suggests that either neutrophil receptors other than Fcgamma RIIa are responsible for CRP mediated responses or differences in CRP binding to the forms of Fcgamma RIIa are comparatively minor.
引用
收藏
页码:271 / 277
页数:7
相关论文
共 40 条
[1]   FcγRIIa expression with FcγRI results in C-reactive protein and IgG-mediated phagocytosis [J].
Bodman-Smith, KB ;
Gregory, RE ;
Harrison, PT ;
Raynes, JG .
JOURNAL OF LEUKOCYTE BIOLOGY, 2004, 75 (06) :1029-1035
[2]   C-reactive protein-mediated phagocytosis and phospholipase D signalling through the high-affinity receptor for immunoglobulin G (FcγRI) [J].
Bodman-Smith, KB ;
Melendez, AJ ;
Campbell, I ;
Harrison, PT ;
Allen, JM ;
Raynes, JG .
IMMUNOLOGY, 2002, 107 (02) :252-260
[3]   FC-GAMMA RECEPTOR IIA (CD32) POLYMORPHISM IN FULMINANT MENINGOCOCCAL SEPTIC SHOCK IN CHILDREN [J].
BREDIUS, RGM ;
DERKX, BHF ;
FIJEN, CAP ;
DEWIT, TPM ;
DEHAAS, M ;
WEENING, RS ;
VANDEWINKEL, JGJ ;
OUT, TA .
JOURNAL OF INFECTIOUS DISEASES, 1994, 170 (04) :848-853
[4]  
Cameron AJM, 2001, EUR J IMMUNOL, V31, P2718, DOI 10.1002/1521-4141(200109)31:9<2718::AID-IMMU2718>3.0.CO
[5]  
2-7
[6]   C-reactive protein binds to both oxidized LDL and apoptotic cells through recognition of a common ligand: Phosphorylcholine of oxidized phospholipids [J].
Chang, MK ;
Binder, CJ ;
Torzewski, M ;
Witztum, JL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (20) :13043-13048
[7]   C-reactive protein induces signaling through FcγRIIa on HL-60 granulocytes [J].
Chi, M ;
Tridandapani, S ;
Zhong, WJ ;
Coggeshall, KM ;
Mortensen, RF .
JOURNAL OF IMMUNOLOGY, 2002, 168 (03) :1413-1418
[8]   Convergence of Fcγ receptor IIA and Fcγ receptor IIIB signaling pathways in human neutrophils [J].
Chuang, FYS ;
Sassaroli, M ;
Unkeless, JC .
JOURNAL OF IMMUNOLOGY, 2000, 164 (01) :350-360
[9]   Pneumolysin activates the synthesis and release of interleukin-8 by human neutrophils in vitro [J].
Cockeran, R ;
Durandt, C ;
Feldman, C ;
Mitchell, TJ ;
Anderson, R .
JOURNAL OF INFECTIOUS DISEASES, 2002, 186 (04) :562-565
[10]  
Culley FJ, 1996, J IMMUNOL, V156, P4691