Common molecular mechanisms in explicit and implicit memory

被引：166

作者：

Barco, Angel

Bailey, Craig H.

Kandel, Eric R. ^{[1
]}

机构：

[1] Columbia Univ, Howard Hughes Med Inst, Ctr Neurobiol & Behav, New York, NY 10032 USA

[2] Inst Neurociencias Alicante UMH CSIC, Alicante, Spain

[3] Coll Phys & Surg Columbia Univ, New York State Psychiat Inst, Ctr Neurobiol & Behav, New York, NY USA

[4] Kavli Brain Inst Brain Sci, New York, NY USA

来源：

JOURNAL OF NEUROCHEMISTRY | 2006年 / 97卷 / 06期

关键词：

aplysia; long-term facilitation; long-term potentiation; memory; molecular bases;

D O I：

10.1111/j.1471-4159.2006.03870.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cellular and molecular studies of both implicit and explicit memory suggest that experience-dependent modulation of synaptic strength and structure is a fundamental mechanism by which these memories are encoded and stored within the brain. In this review, we focus on recent advances in our understanding of two types of memory storage: (i) sensitization in Aplysia, a simple form of implicit memory, and (ii) formation of explicit spatial memories in the mouse hippocampus. These two processes share common molecular mechanisms that have been highly conserved through evolution.

引用

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页码：1520 / 1533

页数：14

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