CR3: a general purpose adhesion-recognition receptor essential for innate immunity

被引：248

作者：

Ehlers, MRW ^{[1
]}

机构：

[1] BioNebraska Inc, Lincoln, NE 68524 USA

来源：

MICROBES AND INFECTION | 2000年 / 2卷 / 03期

关键词：

integrin; phagocytosis; signaling; complement; leukocytes;

D O I：

10.1016/S1286-4579(00)00299-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CR3 (CD11b/CD18), a beta(2) integrin, has a key role in innate antimicrobial defenses, as evidenced by the leukocyte adhesion (CD18) deficiency syndrome in humans and the CD11b knockout mouse. CR3 is a highly versatile pattern-recognition receptor that activates leukocytes via signaling complexes and actin reorganization, mediates phagocytosis, and promotes leukocyte transmigration. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

引用

页码：289 / 294

页数：6

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[3]

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[4] GENERATION OF SIGNALS ACTIVATING NEUTROPHIL FUNCTIONS BY LEUKOCYTE INTEGRINS - LFA-1 AND GP150/95, BUT NOT CR3, ARE ABLE TO STIMULATE THE RESPIRATORY BURST OF HUMAN NEUTROPHILS [J].