What is the real role of CD40 in cancer immunotherapy?

被引：71

作者：

Costello, RT ^{[1
]}

Gastaut, JA

Olive, D

机构：

[1] Univ Mediterranee, Tumour Immunol Unit, F-13009 Marseille, France

[2] Univ Mediterranee, Dept Haematol, F-13009 Marseille, France

[3] Inst J Paoli I Calmettes, INSERM U119, F-13009 Marseille, France

来源：

IMMUNOLOGY TODAY | 1999年 / 20卷 / 11期

关键词：

D O I：

10.1016/S0167-5699(99)01507-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The CD40-CD40 ligand (CD40L) system is of pivotal importance in the immune response via interactions between T cells and antigen-presenting cells. Recent reports have demonstrated that CD40 triggering improves tumour immunogenicity. Nonetheless, as discussed here, the implications of the CD40-CD40L system in host-tumour interactions are pleiotropic and should be evaluated carefully before targeting CD40 for antitumour strategies.

引用

页码：488 / 493

页数：6

共 61 条

[1]

Aggarwal BB, 1996, EUR CYTOKINE NETW, V7, P93

[2] Tumour immunology: false hopes - new horizons? [J].

Alexandroff, AB ;

Robins, RA ;

Murray, A ;

James, K .

IMMUNOLOGY TODAY, 1998, 19 (06) :247-250

[3] THE CD40 ANTIGEN AND ITS LIGAND [J].

BANCHEREAU, J ;

BAZAN, F ;

BLANCHARD, D ;

BRIERE, F ;

GALIZZI, JP ;

VANKOOTEN, C ;

LIU, YJ ;

ROUSSET, F ;

SAELAND, S .

ANNUAL REVIEW OF IMMUNOLOGY, 1994, 12 :881-922

[4] Help for cytotoxic-T-cell responses is mediated by CD40 signalling [J].

Bennett, SRM ;

Carbone, FR ;

Karamalis, F ;

Flavell, RA ;

Miller, JFAP ;

Heath, WR .

NATURE, 1998, 393 (6684) :478-480

[5]

BERBERICH I, 1994, J IMMUNOL, V153, P4357

[6] CD40 and CD95 induce programmed cell death in the human myeloma cell line XG2 [J].

Bergamo, A ;

Bataille, R ;

PellatDeceunynck, C .

BRITISH JOURNAL OF HAEMATOLOGY, 1997, 97 (03) :652-655

[7] Acquired CD40-ligand deficiency in chronic lymphocytic leukemia [J].

Cantwell, M ;

Hua, T ;

Pappas, J ;

Kipps, TJ .

NATURE MEDICINE, 1997, 3 (09) :984-989

[8] EXPRESSION OF FUNCTIONAL CD30 ANTIGEN ON REED-STERNBERG CELLS AND HODGKINS-DISEASE CELL-LINES [J].

CARBONE, A ;

GLOGHINI, A ;

GATTEI, V ;

ALDINUCCI, D ;

DEGAN, M ;

DEPAOLI, P ;

ZAGONEL, V ;

PINTO, A .

BLOOD, 1995, 85 (03) :780-789

[9]

CARBONE A, 1995, AM J PATHOL, V147, P912

[10] A new mechanism of NK cell cytotoxicity activation: The CD40-CD40 ligand interaction [J].

Carbone, E ;

Ruggiero, G ;

Terrazzano, G ;

Palomba, C ;

Manzo, C ;

Fontana, S ;

Spits, H ;

Karre, K ;

Zappacosta, S .

JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 185 (12) :2053-2060

← 1 2 3 4 5 6 7 →