Natural regulatory T cells and parasites: a common quest for host homeostasis

被引：109

作者：

Belkaid, Yasmine ^{[1
]}

Blank, Rebecca B. ^{[1
]}

Suffia, Isabelle ^{[1
]}

机构：

[1] NIAID, Mucosal Immunol Unit, NIH, Parasit Dis Lab, Bethesda, MD 20892 USA

来源：

IMMUNOLOGICAL REVIEWS | 2006年 / 212卷

关键词：

immunity; parasite; regulatory T cells;

D O I：

10.1111/j.0105-2896.2006.00409.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This review discusses the roles played by natural CD4(+)CD25(+) regulatory T cells (natural Tregs) during parasitic infections. Natural Tregs may limit the magnitude of effector responses, which may result in failure to adequately control infection. However, natural Tregs also help to limit collateral tissue damage caused by vigorous antimicrobial immune responses. We discuss the hypothesis that parasites have evolved means to manipulate the host's natural Treg population, thereby generating conditions that secure survival in their vertebrate host for an extended period of time.

引用

页码：287 / 300

页数：14

共 101 条

[1] Human CD4+ CD25+ regulatory T cells control T-cell responses to human immunodeficiency virus and cytomegalovirus antigens [J].

Aandahl, EM ;

Michaëlsson, J ;

Moretto, WJ ;

Hecht, FA ;

Nixon, DF .

JOURNAL OF VIROLOGY, 2004, 78 (05) :2454-2459

[2] PERSISTENCE OF VIRULENT LEISHMANIA-MAJOR IN MURINE CUTANEOUS LEISHMANIASIS - A POSSIBLE HAZARD FOR THE HOST [J].

AEBISCHER, T ;

MOODY, SF ;

HANDMAN, E .

INFECTION AND IMMUNITY, 1993, 61 (01) :220-226

[3] Nonhealing infection despite Th1 polarization produced by a strain of Leishmania major in C57BL/6 mice [J].

Anderson, CF ;

Mendez, S ;

Sacks, DL .

JOURNAL OF IMMUNOLOGY, 2005, 174 (05) :2934-2941

[4] Cutting edge: The prevalence of regulatory T cells lymphoid tissue is correlated with viral load HIV-infected patients [J].

Andersson, J ;

Boasso, A ;

Nilsson, J ;

Zhang, R ;

Shire, NJ ;

Lindback, S ;

Shearer, GM ;

Chougnet, CA .

JOURNAL OF IMMUNOLOGY, 2005, 174 (06) :3143-3147

[5]

[Anonymous], PARASITIC DIS

[6] The early IL-4 response to Leishmania major and the resulting Th2 cell maturation steering progressive disease in BALB/c mice are subject to the control of regulatory CD4+CD25+ T cells [J].

Aseffa, A ;

Gumy, A ;

Launois, P ;

MacDonald, HR ;

Louis, JA ;

Tacchini-Cottier, F .

JOURNAL OF IMMUNOLOGY, 2002, 169 (06) :3232-3241

[7] A unique subpopulation of CD4+ regulatory T cells controls wasting disease, IL-10 secretion and T cell homeostasis [J].

Banz, A ;

Peixoto, A ;

Pontoux, C ;

Cordier, C ;

Rocha, B ;

Papiernik, M .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2003, 33 (09) :2419-2428

[8] Naturally occurring CD4+Foxp3+ regulatory T cells are an essential, IL-10-independent part of the immunoregulatory network in Schistosoma mansoni egg-induced inflammation [J].

Baumgart, Martin ;

Tompkins, Fae ;

Leng, Jin ;

Hesse, Matthias .

JOURNAL OF IMMUNOLOGY, 2006, 176 (09) :5374-5387

[9] TGF-β-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes [J].

Belghith, M ;

Bluestone, JA ;

Barriot, S ;

Mégret, J ;

Bach, JF ;

Chatenoud, L .

NATURE MEDICINE, 2003, 9 (09) :1202-1208

[10] Natural regulatory T cells in infectious disease [J].

Belkaid, Y ;

Rouse, BT .

NATURE IMMUNOLOGY, 2005, 6 (04) :353-360

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