The mouse kinome: Discovery and comparative genomics of all mouse protein kinases

被引：239

作者：

Caenepeel, S

Charydczak, G

Sudarsanam, S

Hunter, T

Manning, G

机构：

[1] SUGEN Inc, Menlo Pk, CA 94025 USA

[2] Salk Inst Biol Studies, La Jolla, CA 92037 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2004年 / 101卷 / 32期

关键词：

D O I：

10.1073/pnas.0306880101

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have determined the full protein kinase (PK) complement (kinome) of mouse. This set of 540 genes includes many novel kinases and corrections or extensions to >150 published sequences. The mouse has orthologs for 510 of the 518 human PIKs. Nonorthologous kinases arise only by retrotransposition and gene decay. Orthologous kinase pairs vary in sequence conservation along their length, creating a map of functionally important regions for every kinase pair. Many species-specific sequence inserts exist and are frequently alternatively spliced, allowing for the creation of evolutionary lineage-specific functions. Ninety-seven kinase pseudogenes were found, all distinct from the 107 human kinase pseudogenes. Chromosomal mapping links 163 kinases to mutant phenotypes and unlocks the use of mouse genetics to determine functions of orthologous human kinases.

引用

页码：11707 / 11712

页数：6

共 31 条

[1] Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity [J].

Biernat, J ;

Wu, YZ ;

Timm, T ;

Zheng-Fischhöfer, QY ;

Mandelkow, E ;

Meijer, L ;

Mandelkow, EM .

MOLECULAR BIOLOGY OF THE CELL, 2002, 13 (11) :4013-4028

[2]

Cheremushkin E, 2003, Pac Symp Biocomput, P291

[3] Protein kinases - the major drug targets of the twenty-first century? [J].

Cohen, P .

NATURE REVIEWS DRUG DISCOVERY, 2002, 1 (04) :309-315

[4] MAPs, MARKs and microtubule dynamics [J].

Drewes, G ;

Ebneth, A ;

Mandelkow, EM .

TRENDS IN BIOCHEMICAL SCIENCES, 1998, 23 (08) :307-311

[5] Phosphoregulators: Protein kinases and protein phosphatases of mouse [J].

Forrest, ARR ;

Ravasi, T ;

Taylor, D ;

Huber, T ;

Hume, DA ;

Grimmond, S .

GENOME RESEARCH, 2003, 13 (6B) :1443-1454

[6] A RECEPTOR GUANYLYL CYCLASE EXPRESSED SPECIFICALLY IN OLFACTORY SENSORY NEURONS [J].

FULLE, HJ ;

VASSAR, R ;

FOSTER, DC ;

YANG, RB ;

AXEL, R ;

GARBERS, DL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (08) :3571-3575

[7] Overview of the Alliance for Cellular Signaling [J].

Gilman, AG ;

Simon, MI ;

Bourne, HR ;

Harris, BA ;

Long, R ;

Ross, EM ;

Stull, JT ;

Taussig, R ;

Bourne, HR ;

Arkin, AP ;

Cobb, MH ;

Cyster, JG ;

Devreotes, PN ;

Ferrell, JE ;

Fruman, D ;

Gold, M ;

Weiss, A ;

Stull, JT ;

Berridge, MJ ;

Cantley, LC ;

Catterall, WA ;

Coughlin, SR ;

Olson, EN ;

Smith, TF ;

Brugge, JS ;

Botstein, D ;

Dixon, JE ;

Hunter, T ;

Lefkowitz, RJ ;

Pawson, AJ ;

Sternberg, PW ;

Varmus, H ;

Subramaniam, S ;

Sinkovits, RS ;

Li, J ;

Mock, D ;

Ning, YH ;

Saunders, B ;

Sternweis, PC ;

Hilgemann, D ;

Scheuermann, RH ;

DeCamp, D ;

Hsueh, R ;

Lin, KM ;

Ni, Y ;

Seaman, WE ;

Simpson, PC ;

O'Connell, TD ;

Roach, T ;

Simon, MI .

NATURE, 2002, 420 (6916) :703-706

[8] A protein kinase encoded by the t complex responder gene causes non-mendelian inheritance [J].

Herrmann, BG ;

Koschorz, B ;

Wertz, K ;

McLaughlin, KJ ;

Kispert, A .

NATURE, 1999, 402 (6758) :141-146

[9] Crystal structure of a tetradecameric assembly of the association domain of Ca2+/calmodulin-dependent kinase II [J].

Hoelz, A ;

Nairn, AC ;

Kuriyan, J .

MOLECULAR CELL, 2003, 11 (05) :1241-1251

[10]

KORK I, 2001, BIOINFORMATICS S1, V17, pS140

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