Leukocyte migration: Scent of the T zone

被引:90
作者
Cyster, JG [1 ]
机构
[1] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA
关键词
D O I
10.1016/S0960-9822(99)00253-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Recent studies show that the chemokine receptor CCR7 helps T lymphocytes and dendritic cells to navigate into the T-cell zone of lymphoid organs. Furthermore, downmodulation of CCR7 redirects some activated T cells from these zones into other lymphoid tissue compartments.
引用
收藏
页码:R30 / R33
页数:4
相关论文
共 17 条
[1]   In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines [J].
Ansel, KM ;
McHeyzer-Williams, LJ ;
Ngo, VN ;
McHeyzer-Williams, MG ;
Cyster, JG .
JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 190 (08) :1123-1134
[2]   Chemokines and the arrest of lymphocytes rolling under flow conditions [J].
Campbell, JJ ;
Hedrick, J ;
Zlotnik, A ;
Siani, MA ;
Thompson, DA ;
Butcher, EC .
SCIENCE, 1998, 279 (5349) :381-384
[3]   Chemokines and the homing of dendritic cells to the T cell areas of lymphoid organs [J].
Cyster, JG .
JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (03) :447-450
[4]   CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs [J].
Förster, R ;
Schubel, A ;
Breitfeld, D ;
Kremmer, E ;
Renner-Müller, I ;
Wolf, E ;
Lipp, M .
CELL, 1999, 99 (01) :23-33
[5]   Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization [J].
Gunn, MD ;
Kyuwa, S ;
Tam, C ;
Kakiuchi, T ;
Matsuzawa, A ;
Williams, LT ;
Nakano, H .
JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (03) :451-460
[6]   Immunology - Dual personality of memory T cells [J].
Mackay, CR .
NATURE, 1999, 401 (6754) :659-660
[7]   A novel mutant gene involved in T-lymphocyte-specific homing into peripheral lymphoid organs on mouse chromosome 4 [J].
Nakano, H ;
Mori, S ;
Yonekawa, H ;
Nariuchi, H ;
Matsuzawa, A ;
Kakiuchi, T .
BLOOD, 1998, 91 (08) :2886-2895
[8]  
Potsch C, 1999, EUR J IMMUNOL, V29, P3562, DOI 10.1002/(SICI)1521-4141(199911)29:11<3562::AID-IMMU3562>3.0.CO
[9]  
2-R
[10]   The role of CCR7 in TH1 and TH2 cell localization and delivery of B cell help in vivo [J].
Randolph, DA ;
Huang, GM ;
Carruthers, CJL ;
Bromley, LE ;
Chaplin, DD .
SCIENCE, 1999, 286 (5447) :2159-2162