Cell cycle and death control: long live Forkheads

被引：587

作者：

Burgering, BMT

Kops, GJPL

机构：

[1] Univ Utrecht, Dept Physiol Chem, Stratenum, NL-3584 CG Utrecht, Netherlands

[2] Univ Utrecht, Ctr Biomed Genet, Stratenum, NL-3584 CG Utrecht, Netherlands

[3] Univ Calif San Diego, Ludwig Inst Canc Res, La Jolla, CA 92093 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2002年 / 27卷 / 07期

关键词：

D O I：

10.1016/S0968-0004(02)02113-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The FOXO family of Forkhead transcription factors, FKHR (FOXO1), FKHR-L1 (FOXO3a) and AFX (FOXO4), are regulated by the phosphoinositide-3-kinase-protein-kinase-B (PI3K-PKB/c-Akt) pathway. Direct phosphorylation by PKB results in cytoplasmic retention and inactivation, inhibiting the expression of FOXO-regulated genes, which control the cell cycle, cell death, cell metabolism and oxidative stress. This pathway appears to be well conserved throughout evolution. In the nematode Caenorhabditis elegans, it affects lifespan and controls dauer formation. Recent discoveries about FOXO regulation by PI3K-PKB signalling suggest that the PI3K-PKB-FOXO pathway might participate in similar processes in higher eukaryotes.

引用

收藏

页码：352 / 360

页数：9

相关论文

共 65 条

[1] Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B alpha [J].

Alessi, DR ;

James, SR ;

Downes, CP ;

Holmes, AB ;

Gaffney, PRJ ;

Reese, CB ;

Cohen, P .

CURRENT BIOLOGY, 1997, 7 (04) :261-269

[2] Molecular basis for the substrate specificity of protein kinase B; Comparison with MAPKAP kinase-1 and p70 S6 kinase [J].

Alessi, DR ;

Caudwell, FB ;

Andjelkovic, M ;

Hemmings, BA ;

Cohen, P .

FEBS LETTERS, 1996, 399 (03) :333-338

[3] Mechanism of activation of protein kinase B by insulin and IGF-1 [J].

Alessi, DR ;

Andjelkovic, M ;

Caudwell, B ;

Cron, P ;

Morrice, N ;

Cohen, P ;

Hemmings, BA .

EMBO JOURNAL, 1996, 15 (23) :6541-6551

[4] Forkhead transcription factors contribute to execution of the mitotic programme in mammals [J].

Alvarez, B ;

Martinez, C ;

Burgering, BMT ;

Carrera, AC .

NATURE, 2001, 413 (6857) :744-747

[5] Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B [J].

Anderson, KE ;

Coadwell, J ;

Stephens, LR ;

Hawkins, PT .

CURRENT BIOLOGY, 1998, 8 (12) :684-691

[6] Gene fusions involving PAX and FOX family members in alveolar rhabdomyosarcoma [J].

Barr, FG .

ONCOGENE, 2001, 20 (40) :5736-5746

[7] The free radical theory of aging matures [J].

Beckman, KB ;

Ames, BN .

PHYSIOLOGICAL REVIEWS, 1998, 78 (02) :547-581

[8] Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1 [J].

Biggs, WH ;

Meisenhelder, J ;

Hunter, T ;

Cavenee, WK ;

Arden, KC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (13) :7421-7426

[9] Ten years of protein kinase B signalling: a hard Akt to follow [J].

Brazil, DP ;

Hemmings, BA .

TRENDS IN BIOCHEMICAL SCIENCES, 2001, 26 (11) :657-664

[10] Drosophila's insulin/P13-kinase pathway coordinates cellular metabolism with nutritional conditions [J].

Britton, JS ;

Lockwood, WK ;

Li, L ;

Cohen, SM ;

Edgar, BA .

DEVELOPMENTAL CELL, 2002, 2 (02) :239-249

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