Development of heart valve leaflets and supporting apparatus in chicken and mouse embryos

被引:193
作者
Lincoln, J [1 ]
Alfieri, CM [1 ]
Yutzey, KE [1 ]
机构
[1] Childrens Hosp, Med Ctr, Div Mol Cardiovasc Biol, Cincinnati, OH 45229 USA
关键词
heart; valve remodeling; chicken; mouse;
D O I
10.1002/dvdy.20051
中图分类号
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号
100101 ;
摘要
Abnormalities in valvuloseptal development significantly contribute to congenital heart defects, yet the underlying causes are complex and poorly understood. Early cardiac regulatory genes are differentially expressed during valvuloseptal development, consistent with novel functions during heart chamber formation in chicken and mouse embryos. Distinct valve cell lineages were identified in the leaflets, chordae tendineae, and myotendinous junctions with the papillary muscles based on restricted expression of extracellular matrix molecules. Specific cell types within these structures demonstrate characteristics of chondrogenesis and tendon development, identified by scleraxis, type II collagen, and tenascin expression. In chicken embryos, valve remodeling and maturation accompanies a decrease in mitotic index indicated by reduced bromodeoxyuridine incorporation. Analysis of Tie2-cre x ROSA26R mice demonstrates that mature valve structures, including the atrioventricular and outflow tract semilunar valve leaflets, chordae tendineae, and the fibrous continuity that connects the septal leaflets of mitral and tricuspid valves, arise from endothelial cells of the endocardial cushions. Together, these studies provide novel insights into the origins and cell lineage diversity of mature valve structures in the developing vertebrate heart. (C) 2004 Wiley-Liss, Inc.
引用
收藏
页码:239 / 250
页数:12
相关论文
共 80 条
[1]   Overlapping and differential localization of Bmp-2, Bmp-4, Msx-2 and apoptosis in the endocardial cushion and adjacent tissues of the developing mouse heart [J].
Abdelwahid, E ;
Rice, D ;
Pelliniemi, LJ ;
Jokinen, E .
CELL AND TISSUE RESEARCH, 2001, 305 (01) :67-78
[2]   IMMUNOCHEMICAL ANALYSIS OF MYOSIN HEAVY-CHAIN DURING AVIAN MYOGENESIS INVIVO AND INVITRO [J].
BADER, D ;
MASAKI, T ;
FISCHMAN, DA .
JOURNAL OF CELL BIOLOGY, 1982, 95 (03) :763-770
[3]  
Barnett Joey V., 2003, Birth Defects Research, V69, P58, DOI 10.1002/bdrc.10006
[4]   Congenital polyvalvular disease: A review [J].
Bartram, U ;
Bartelings, MM ;
Kramer, HH ;
Gittenberger-de Groot, AC .
PEDIATRIC CARDIOLOGY, 2001, 22 (02) :93-101
[5]   Mutations in human cause limb and cardiac malformation in Holt-Oram syndrome [J].
Basson, CT ;
Bachinsky, DR ;
Lin, RC ;
Levi, T ;
Elkins, JA ;
Soults, J ;
Grayzel, D ;
Kroumpouzou, E ;
Traill, TA ;
LeblancStraceski, J ;
Renault, B ;
Kucherlapati, R ;
Seidman, JG ;
Seidman, CE .
NATURE GENETICS, 1997, 15 (01) :30-35
[6]   Cardiac septal and valvular dysmorphogenesis in mice heterozygous for mutations in the homeobox gene Nkx2-5 [J].
Biben, C ;
Weber, R ;
Kesteven, S ;
Stanley, E ;
McDonald, L ;
Elliott, DA ;
Barnett, L ;
Köentgen, F ;
Robb, L ;
Feneley, M ;
Harvey, RP .
CIRCULATION RESEARCH, 2000, 87 (10) :888-895
[7]   Heart development: molecular insights into cardiac specification and early morphogenesis [J].
Brand, T .
DEVELOPMENTAL BIOLOGY, 2003, 258 (01) :1-19
[8]   Transcriptional regulation of vertebrate cardiac morphogenesis [J].
Bruneau, BG .
CIRCULATION RESEARCH, 2002, 90 (05) :509-519
[9]   A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease [J].
Bruneau, BG ;
Nemer, G ;
Schmitt, JP ;
Charron, F ;
Robitaille, L ;
Caron, S ;
Conner, DA ;
Gessler, M ;
Nemer, M ;
Seidman, CE ;
Seidman, JG .
CELL, 2001, 106 (06) :709-721
[10]  
Chapman DL, 1996, DEV DYNAM, V206, P379, DOI 10.1002/(SICI)1097-0177(199608)206:4<379::AID-AJA4>3.0.CO