4-thiazolidinones: Novel inhibitors of the bacterial enzyme MurB

被引：215

作者：

Andres, CJ

Bronson, JJ

D'Andrea, SV

Deshpande, MS

Falk, PJ

Grant-Young, KA

Harte, WE

Ho, HT

Misco, PF

Robertson, JG

Stock, D

Sun, YX

Walsh, AW

机构：

[1] Bristol Myers Squibb Co, Pharmaceut Res Inst, Wallingford, CT 06492 USA

[2] Bristol Myers Squibb Pharmaceut Res Inst, Princeton, NJ 08543 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(00)00073-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Thiazolidinones were synthesized and evaluated for their ability to inhibit the bacterial enzyme MurB. Selected 4-thiazolidinones displayed activity against the enzyme in vitro. This activity, coupled with the design principles of the thiazolidinones, supports the postulate that 4-thiazolidinones may be recognized as diphosphate mimics by a biological selector. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：715 / 717

页数：3

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