Obese gene expression alters the ability of 30A5 preadipocytes to respond to lipogenic hormones

被引：197

作者：

Bai, YL ^{[1
]}

Zhang, SY ^{[1
]}

Kim, KS ^{[1
]}

Lee, JK ^{[1
]}

Kim, KH ^{[1
]}

机构：

[1] PURDUE UNIV,DEPT BIOCHEM,W LAFAYETTE,IN 47907

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 1996年 / 271卷 / 24期

关键词：

D O I：

10.1074/jbc.271.24.13939

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Leptin, the product of the oh gene, controls food-intake and weight loss in the ob mouse. Although the target(s) of the circulating leptin is presumed to be the brain which then orchestrates food-intake and weight loss, how leptin functions in the process of weight loss is unknown. In this report, we present evidence that ob gene expression in cultured cells suppresses acetyl-CoA carboxylase gene expression and lipid synthesis which are induced by hormone treatment. This is the first example in which leptin has been found to suppress defined biochemical reactions that contribute to Lipid accumulation without the participation of the brain.

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页码：13939 / 13942

页数：4

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