Promoter targeting and chromatin remodeling by the SWI/SNF complex

被引：381

作者：

Peterson, CL ^{[1
]}

Workman, JL

机构：

[1] Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA

[2] Univ Massachusetts, Sch Med, Dept Biochem & Mol Biol, Worcester, MA 01605 USA

[3] Univ Massachusetts, Sch Med, Dept Biochem & Mol Biol, Worcester, MA 01605 USA

[4] Penn State Univ, Howard Hughes Med Inst, University Pk, PA 16802 USA

[5] Penn State Univ, Dept Biochem & Mol Biol, University Pk, PA 16802 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2000年 / 10卷 / 02期

关键词：

D O I：

10.1016/S0959-437X(00)00068-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The SWI/SNF complex is a 2 MDa multi-subunit DNA-dependent ATPase that contributes to the regulation of gene transcription by altering chromatin structure. Recent studies have revealed that the SWI/SNF complex is targeted to promoters via direct interactions with transcription activators and have provided insights into mechansims by which the complex alters nucleosome structure and contributes to the remodeling of chromatin.

引用

页码：187 / 192

页数：6

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