p75NTR is positively promiscuous: Novel partners and new insights

被引：260

作者：

Barker, PA ^{[1
]}

机构：

[1] McGill Univ, Montreal Neurol Inst, Montreal, PQ H3A 2B4, Canada

来源：

NEURON | 2004年 / 42卷 / 04期

关键词：

D O I：

10.1016/j.neuron.2004.04.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Although identified almost 20 years ago, the precise physiological role of the p75 neurotrophin receptor (p75NTR) has remained elusive. Recent studies have revealed that p75NTR is a component of three distinct receptor platforms that bind different ligands and that, under differing circumstances, facilitate cell survival, cell death, or growth inhibition. These recent developments provide new insights into the functions of this enigmatic receptor.

引用

页码：529 / 533

页数：5

共 26 条

[1] ProNGF induces p75-mediated death of oligodendrocytes following spinal cord injury [J].

Beattie, MS ;

Harrington, AW ;

Lee, R ;

Kim, JY ;

Boyce, SL ;

Longo, FM ;

Bresnahan, JC ;

Hempstead, BL ;

Yoon, SO .

NEURON, 2002, 36 (03) :375-386

[2]

Bhakar AL, 2003, J NEUROSCI, V23, P11373

[3] The neurotrophin receptors, trkB and p75, differentially regulate motor axonal regeneration [J].

Boyd, JG ;

Gordon, T .

JOURNAL OF NEUROBIOLOGY, 2001, 49 (04) :314-325

[4] Rho activation patterns after spinal cord injury and the role of activated Rho in apoptosis in the central nervous system [J].

Dubreuil, CI ;

Winton, MJ ;

McKerracher, L .

JOURNAL OF CELL BIOLOGY, 2003, 162 (02) :233-243

[5] CRNF, a molluscan neurotrophic factor that interacts with the p75 neurotrophin receptor [J].

Fainzilber, M ;

Smit, AB ;

Syed, NI ;

Wildering, WC ;

Hermann, PM ;

vanderSchors, RC ;

Jimenez, C ;

Li, KW ;

vanMinnen, J ;

Bulloch, AGM ;

Ibanez, CF ;

Geraerts, WPM .

SCIENCE, 1996, 274 (5292) :1540-1543

[6] Regulation, cellular localization, and function of the p75 neurotrophin receptor (p75NTR) during the regeneration of facial motoneurons [J].

Gschwendtner, A ;

Liu, ZQ ;

Hucho, T ;

Bohatschek, M ;

Kalla, R ;

Dechant, G ;

Raivich, G .

MOLECULAR AND CELLULAR NEUROSCIENCE, 2003, 24 (02) :307-322

[7]

HARRINGTON AW, 2004, IN PRESS P NATL ACAD

[8] Structure of nerve growth factor complexed with the shared neurotrophin receptor p75 [J].

He, XL ;

Garcia, KC .

SCIENCE, 2004, 304 (5672) :870-875

[9] Proteolytic processing of the p75 neurotrophin receptor and two homologs generates C-terminal fragments with signaling capability [J].

Kanning, KC ;

Hudson, M ;

Amieux, PS ;

Wiley, JC ;

Bothwell, M ;

Schecterson, LC .

JOURNAL OF NEUROSCIENCE, 2003, 23 (13) :5425-5436

[10] TARGETED MUTATION OF THE GENE ENCODING THE LOW AFFINITY NGF RECEPTOR P75 LEADS TO DEFICITS IN THE PERIPHERAL SENSORY NERVOUS-SYSTEM [J].

LEE, KF ;

LI, E ;

HUBER, LJ ;

LANDIS, SC ;

SHARPE, AH ;

CHAO, MV ;

JAENISCH, R .

CELL, 1992, 69 (05) :737-749

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