Lymphoid precursors

被引：62

作者：

Akashi, K

Reya, T

Dalma-Weiszhausz, D

Weissman, IL

机构：

[1] Stanford Univ, Sch Med, Beckman Ctr B261, Dept Pathol, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Dev Biol, Stanford, CA 94305 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2000年 / 12卷 / 02期

关键词：

D O I：

10.1016/S0952-7915(99)00064-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Lymphopoiesis of mature and diverse populations of T, B and NK (natural killer) cells from multipotent hematopoietic stem cells is an ideal model of tissue generation and regeneration. Identification and isolation of hematolymphoid stem and progenitor cells in several laboratories over the past several years have provided populations that can be studied biologically for lineage commitment and biochemically for receptor function, signal transduction and selective gene expression. These studies may ultimately provide candidate genes involved in lineage commitment, cell death or survival, self-renewal and migratory capacities of progenitors.

引用

收藏

页码：144 / 150

页数：7

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