Improved microbial gene identification with GLIMMER

被引：1987

作者：

Delcher, AL ^{[1
]}

Harmon, D

Kasif, S

White, O

Salzberg, SL

机构：

[1] Loyola Coll, Dept Comp Sci, Baltimore, MD 21210 USA

[2] Celera Genom, Rockville, MD 20850 USA

[3] Univ Illinois, Dept Elect Engn & Comp Sci, Chicago, IL 60607 USA

[4] Inst Genom Res, Rockville, MD 20850 USA

来源：

NUCLEIC ACIDS RESEARCH | 1999年 / 27卷 / 23期

关键词：

D O I：

10.1093/nar/27.23.4636

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The GLIMMER system for microbial gene identification finds similar to 97-98% of all genes in a genome when compared with published annotation. This paper reports on two new results: (i) significant technical improvements to GLIMMER that improve its accuracy still further, and (ii) a comprehensive evaluation that demonstrates that the accuracy of the system is likely to be higher than previously recognized. A significant proportion of the genes missed by the system appear to be hypothetical proteins whose existence is only supported by the predictions of other programs. When the analysis is restricted to genes that have significant homology to genes in other organisms, GLIMMER misses <1% of known genes.

引用

页码：4636 / 4641

页数：6

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