Non-HDL cholesterol is an independent risk factor for aspirin resistance in obese patients with type 2 diabetes

被引：19

作者：

Kim, Jong Dai ^{[1
]}

Park, Cheol-Young ^{[1
]}

Ahn, Kue Jeong ^{[2
]}

Cho, Jae Hyoung ^{[3
]}

Choi, Kyung Mook ^{[4
]}

Kang, Jun Goo ^{[5
]}

Kim, Jae Hyeon ^{[6
]}

Lee, Ki Young

Lee, Byung Wan ^{[7
,8
]}

Mok, Ji Oh ^{[9
]}

Moon, Min Kyong ^{[10
]}

Park, Joong Yeol ^{[11
]}

Park, Sung Woo ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Coll Med, Dept Internal Med,Div Endocrinol & Metab, Seoul 110746, South Korea

[2] Kyung Hee Univ, Gangdong Kyunghee Hosp, Coll Med, Dept Internal Med,Div Endocrinol & Metab, Seoul, South Korea

[3] Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Internal Med,Div Endocrinol & Metab, Seoul, South Korea

[4] Korea Univ, Coll Med, Korea Univ Guro Hosp, Dept Internal Med,Div Endocrinol & Metab, Seoul 136705, South Korea

[5] Hallym Univ, Pyungchon Sacred Heart Hosp, Coll Med, Dept Internal Med,Div Endocrinol & Metab, Anyang, Gyunggi Do, South Korea

[6] Sungkyunkwan Univ, Samsung Seoul Hosp, Coll Med, Dept Internal Med,Div Endocrinol & Metab, Seoul 110746, South Korea

[7] Gacheon Univ, Gil Hosp, Coll Med, Dept Internal Med,Div Endocrinol & Metab, Inchon, South Korea

[8] Yonsei Univ, Coll Med, Dept Internal Med, Severance Hosp,Div Endocrinol & Metab, Seoul, South Korea

[9] Soonchunhyang Univ, Bucheon Soonchunhyang Hosp, Sch Med, Dept Internal Med,Div Endocrinol & Metab, Puchon, Gyunggi Do, South Korea

[10] Seoul Natl Univ, Boramae Hosp, Coll Med, Dept Internal Med,Div Endocrinol & Metab, Puchon, Gyunggi Do, South Korea

[11] Univ Ulsan, Seoul Asan Hosp, Coll Med, Dept Internal Med,Div Endocrinol & Metab, Seoul, South Korea

来源：

ATHEROSCLEROSIS | 2014年 / 234卷 / 01期

关键词：

Aspirin resistance; Non-HDL cholesterol; Atherogenic dyslipidemia; Diabetes; CORONARY-ARTERY-DISEASE; LOW-DENSITY-LIPOPROTEIN; PLATELET-FUNCTION; PREVALENCE; AGGREGATION; CLOPIDOGREL; REACTIVITY; MORTALITY; EVENTS;

D O I：

10.1016/j.atherosclerosis.2014.01.015

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: We evaluated the prevalence of aspirin resistance and predictive factors for aspirin resistance in Korean type 2 diabetes patients. Approach and results: A total of 1045 type 2 diabetes patients from 11 hospitals who were taking aspirin (100 mg/day for >= 2 weeks) and no other antiplatelet agents were studied to evaluate aspirin resistance. Aspirin resistance was measured in aspirin reaction units using VerifyNow (R). Aspirin resistance was defined as >= 550 aspirin reaction units. Aspirin resistance was detected in 102 of the 1045 subjects (prevalence 9.8%). Aspirin resistance was associated with total cholesterol (P = 0.013), LDL-cholesterol (P = 0.028), and non-HDL cholesterol (P = 0.008) concentrations in univariate analysis. In multivariate logistic regression analysis, only non-HDL cholesterol was associated with aspirin resistance in obese (BMI > 25 kg/m(2)) type 2 diabetes patients (adjusted odds ratio 3.55, 95% CI: 1.25-10.05, P = 0.017). Conclusions: The prevalence of aspirin resistance in Korean type 2 diabetes patients is 9.8%. Non-HDL cholesterol is an independent risk factor for aspirin resistance, especially in obese type 2 diabetes patients. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

引用

页码：146 / 151

页数：6

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