Dimerization in MAP-kinase signaling

被引：129

作者：

Cobb, MH

Goldsmith, EJ

机构：

[1] Univ Texas, SW Med Ctr, Dept Pharmacol, Dallas, TX 75235 USA

[2] Univ Texas, SW Med Ctr, Dept Biochem, Dallas, TX 75235 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2000年 / 25卷 / 01期

关键词：

D O I：

10.1016/S0968-0004(99)01508-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The stimulus-dependent nuclear localization of the extracellular-signal-regulated kinases ERK1 and ERK2 is required for many of their actions, including induction of neurites in PC12 cells and transformation of fibroblasts. Phosphorylation of ERK2 causes it to form dimers, and the most flexible portions of the ERK2 molecule provide the surfaces for dimerization. It is thought that dimerization promotes nuclear localization of ERK2 by its effects on import, export or retention in cytoplasmic and nuclear compartments. Dimerization might also influence substrate interactions.

引用

收藏

页码：7 / 9

页数：3

相关论文

共 28 条

[1] Two co-existing mechanisms for nuclear import of MAP kinase: passive diffusion of a monomer and active transport of a dimer [J].

Adachi, M ;

Fukuda, M ;

Nishida, E .

EMBO JOURNAL, 1999, 18 (19) :5347-5358

[2] Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry [J].

Brunet, A ;

Roux, D ;

Lenormand, P ;

Dowd, S ;

Keyse, S ;

Pouysségur, J .

EMBO JOURNAL, 1999, 18 (03) :664-674

[3] Activation mechanism of the MAP kinase ERK2 by dual phosphorylation [J].

Canagarajah, BJ ;

Khokhlatchev, A ;

Cobb, MH ;

Goldsmith, EJ .

CELL, 1997, 90 (05) :859-869

[4] A HOT-SPOT OF BINDING-ENERGY IN A HORMONE-RECEPTOR INTERFACE [J].

CLACKSON, T ;

WELLS, JA .

SCIENCE, 1995, 267 (5196) :383-386

[5] HOW MAP KINASES ARE REGULATED [J].

COBB, MH ;

GOLDSMITH, EJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (25) :14843-14846

[6]

COBB MH, 1989, J BIOL CHEM, V264, P18701

[7] The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes [J].

Ferrell, JE ;

Machleder, EM .

SCIENCE, 1998, 280 (5365) :895-898

[8] Cytoplasmic localization of mitogen-activated protein kinase kinase directed by its NH2-terminal, leucine-rich short amino acid sequence, which acts as a nuclear export signal [J].

Fukuda, M ;

Gotoh, I ;

Gotoh, Y ;

Nishida, E .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (33) :20024-20028

[9] CRM1 is responsible for intracellular transport mediated by the nuclear export signal [J].

Fukuda, M ;

Asano, S ;

Nakamura, T ;

Adachi, M ;

Yoshida, M ;

Yanagida, M ;

Nishida, E .

NATURE, 1997, 390 (6657) :308-311

[10] Interaction of MAP kinase with MAP kinase kinase: Its possible role in the control of nucleocytoplasmic transport of MAP kinase [J].

Fukuda, M ;

Gotoh, Y ;

Nishida, E .

EMBO JOURNAL, 1997, 16 (08) :1901-1908