The neurochemistry of Alzheimer's disease

被引：10

作者：

Blennow, K ^{[1
]}

Cowburn, RF ^{[1
]}

机构：

[1] KAROLINSKA INST, NOVUM, GERIATR MED SECT, HUDDINGE, SWEDEN

来源：

ACTA NEUROLOGICA SCANDINAVICA | 1996年 / 94卷

关键词：

Alzheimer's disease; amyloid; apolipoprotein E; neurofibrillary tangle; tau; presenilin; cerebrospinal fluid; postmortem brain; senile plaques;

D O I：

10.1111/j.1600-0404.1996.tb00378.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The last 15-20 years have seen a wealth of studies to characterize the neurochemical abnormalities of Alzheimer's disease, in particular those involving the beta-amyloid and tau proteins, as well as more recently, apolipoprotein E4. This article provides a summary of the evidence for the involvement of these proteins in Alzheimer's disease pathogenesis based on postmortem brain and CSF studies.

引用

页码：77 / 86

页数：10

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